electroluminescent material or element. ;CONSTITUTION: This blue-emitting org. electroluminescent material is a poly(3,4- substd.-1,6-phenyleneethynylene) represented by the formula. An electroluminescent element is prepd. from the material. In the formula, R...
The fundamental element behind determining the accuracy of a protein–ligand docking algorithm is the generated scoring function during the docking study [71]. Swiftness and precision are the two essential aspects of any scoring function. An ideal scoring function would be both computationally proficient...
Assuming genetic variants as the “first hits” in a multifactorial disease model, assessing the top genes associated with MDD offers valid biological insight into its onset. Combined with environmental stressors, these variants may induce alterations of small effect at the cellular and physiological l...
W. Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels support a selective response to EPSPs in preference to action potentials . J. Neurosci. 20, 266? 273 (2000). Article CAS PubMed PubMed Central Google Scholar Berridge, M. J. Neuronal ...
The training set consists of three categories of molecules: Nmol—molecules containing element N (nitrogen) but lacking F (fluorine), labeled as negative; Fmol—molecules containing element F but lacking N, labeled as positive; and N_Fmol—molecules containing both elements N and F, randomly ...
An algorithm for filtering molecular formulas is derived from seven heuristic rules: (1) restrictions for the number of elements, (2) LEWIS and SENIOR chemical rules, (3) isotopic patterns, (4) hydrogen/carbon ratios, (5) element ratio of nitrogen, oxygen, phosphor, and sulphur versus carbon...
“Photosynthesis” (Additional file1: Table S10). In addition, the top 10 enriched pathways also included pathway of “Nitrogen metabolism,” which belongs to “Energy metabolism” at level 2 class, and nitrogen is an essential element for amino acid synthesis. These results provide clues forV....
we write optimized substructures such that nodes with the rarest element, highest property specification and aromaticity as well as high order or aromatic bond definitions occur first. Additionally, we place substructure parts that are rather common or difficult to process at the end of the formulati...
elevated intracellular ROS induced sustained expression of HIF-1α protein.91The accumulated HIF-1α binds to HIF-1β and enters the nucleus to bind the hypoxia response element (HRE) in the promoter region of the target gene to reduce cellular oxygen consumption.92,93HIF-3α exerts the oppos...
Yi et al. found that silencing of sterol regulatory element-binding proteins 1 (SREBP1) reduced SCD1 expression to promote lipid peroxidation and induce ferroptosis in PCa cells [75]. In addition, the researchers also found that the PI3K/AKT/mTOR pathway can inhibit ferroptosis through the ...