The native conformation of the ribonucleoproteins (RNP) and its higher-order assemblies were revealed. Overall, these characterizations have revealed the architecture of the SARS-CoV-2 virus in unprecedented detail, and shed lights on how the virus packs its 30 kb long single-segmented RNA in the...
2020年10月29日,在Cell(IF=64.5)在线发表题为“Molecular Architecture of the SARS-CoV-2 Virus”的研究论文,作者通过使用冷冻电子断层扫描(cryo-ET)和亚断层扫描平均(STA)对真正的SARS-CoV-2病毒进行了分子组装。 image.png 2021年1月28日,在Science(IF=56.9)在线发表题为“Structure of the activated human ...
Molecular structure analyses suggest strategies to therapeutically target SARS-CoV-2Structural biologyElectron microscopyX-ray crystallographyDiseasesDomain architecture of the SARS-CoV-2 spike protein. Receptor-binding domain (RBD), heptad repeats (HR1 and HR2), transmembrane domain (TP), and protease ...
2020年10月29日,在Cell(IF=64.5)在线发表题为“Molecular Architecture of the SARS-CoV-2 Virus”的研究论文,作者通过使用冷冻电子断层扫描(cryo-ET)和亚断层扫描平均(STA)对真正的SARS-CoV-2病毒进行了分子组装。 2021年1月28日,在Science(IF=56.9)在线发表题为“Structure of the activated human minor splic...
(PDB ID: 6LZG). It is divided into two subdomains: the β-sheet-dominated conserved core domain, which is stabilized by a disulfide bond between βc2 and βc4, and the loop-dominated external domain, which contains two small β-sheets. The architecture of dACE2 is also similar to that...
The mechanism of DMV pore complex formation remains unknown. Here we describe the molecular architecture of the SARS-CoV-2 nsp3–nsp4 pore complex, as resolved by cryogenic electron tomography and subtomogram averaging in isolated DMVs. The structures uncover an unexpected stoichiometry and topology ...
The architecture of SARS-CoV-2 transcriptome Cell., 181 (2020), pp. 1-8 Google Scholar Kim et al., 2020b Y. Kim, R. Jedrzejczak, N.I. Maltseva, M. Wilamowski, M. Endres, A. Godzik, et al. Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2 Protein Sci., 29 ...
Architecture of the SARS coronavirus ... DR Beniac,A Andonov,E Grudeski,... - 《Nature Structural & Molecular Biology》 被引量: 122发表: 2006年 RNA Recognition and Cleavage by the SARS Coronavirus Endoribonuclease Journal of Molecular BiologyBhardwaj K., Sun J., Holzenburg A., Guarino L...
The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report that suramin, a 100-year-old drug, is a potent inhibitor of the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and acts by blocking the binding of RNA to...
SARS-CoV-2 evolution, prevalence, and genome architecture.aPhylogenetic analysis of sequence divergence of SARS-CoV-2 circulating variants based on clade classification in February 2022. The WHO labeling of clades is marked besides.bSequential frequency of major clades of SARS-CoV-2 variants from Ap...