We analysed the ligand-based activation mechanism of the prostate-specific G-protein coupled receptor (PSGR), which is an olfactory receptor that mediates cellular growth in prostate cancer cells. Furthermore, it is an olfactory receptor with a known che
Engineered biosynthesis of mevalonic acid proceeds from acetyl-CoA units through condensation to acetoacetyl-CoA (by AtoB) and 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA; by ERG13) prior to reduction with NADPH to form mevalonic acid (by tHMGR)30,31,32. Growth impairment from mevalonic acid p...
Issuing this command could negatively impact system performance depending on the number of subscribers for which monitoring is performed and/or the amount of data they're passing. Example The following command enables the monitoring of user user1 and mobile s...
Biosynthetic thiolase catalyzes the formation of acetoacetyl-CoA from two molecules of acetylCoA. This is a key step in the synthesis of many biological compounds, including steroid hormones and ketone bodies. The thiolase reaction involves two chemically distinct steps; during acyl transfer, an ...
which can be attributed to a reduction in the levels of serum FFAs in NA/STZ-induced diabetic rats. Adiponectin increases the oxidation of a muscle’s fatty acid and glucose transport via the phosphorylation of AMP-activated protein kinase (AMPK) or Akt [66] and Acetyl-CoA carboxylase inhibiti...
In this analysis, some parameters included in the CIGRE data were used to assess the risk factors. The severity considers parameters related to the effects of failures in power transformers, the damage of the failures to the environment and themselves, their reparability, and the duration of the...
Issuing this command could negatively impact system performance depending on the number of subscribers for which monitoring is performed and/or the amount of data they're passing. Example The following command enables the monitoring of user user1 and mobile subscriber ID 44412...
We will review here the different putative γδ TCR ligands that have been found recently and in the past and discuss the data which support their role in TCR ligation. Through a more detailed description of a few murine and human models which have been extensively studied, we will discuss ...
The location of poxB and mqsR close to each other, next to transposase coding genes and at the end of a contig (Additional file 1 Figure S4), suggests that both genes may have been acquired by a horizontal gene transfer event from another microorganism. The oxygen concentration drops ...
Monomeric sarcosine oxidase, from a bacterial source, is a 43.8 kDa flavoenzyme that catalyzes the oxidation of sarcosine ( N -methylglycine). The enzyme forms charge-transfer (CT) complexes with substrate analogs such as (methylthio)acetic acid (MTA), pyrrole-2-carboxylic acid (PCA) and (...