A hybrid-system model of the coagulation cascade: Simulation, sensitivity, and validation. Journal of bioinformatics and computational biology. 2013; 11(05):1342004. doi: 10. 1142/S0219720013420043 PMID: 24131053Makin JG, Narayanan S, A hybrid-system model of the coagulation cascade: Simulation, ...
2018, Physics of Life Reviews Citation Excerpt : There are numerous works devoted to modeling the coagulation cascade under different simplifying assumptions, these are necessary since the complete reaction scheme is complex and not completely known, especially if platelets are involved. In vitro coagula...
Levels of coagulation factor activities at birth in noncatheterized animals were not different from those found in catheterized animals except for factor IX activity which was 12%higher in the catheterized animals (0.02 t P < 0.05). The patterns of development for each of the coagulation ...
Tissue factor (TF) is a low molecular weight glycoprotein that initiates the clotting cascade and is considered to be a major regulator of coagulation, hem... MB Taubman,JD Marmur,CL Rosenfield,... - 《Journal of Clinical Investigation》 被引量: 440发表: 1993年 High prevalence of occult ...
In order to confirm which process is the most important in the blood coagulation cascade, a dynamic model of the function of platelets in blood coagulation is provided based on biochemical experiments. A series of conclusions based on qualitative analysis and mathematical simulation are drawn about ...
Thrombus formation on a disrupted atherosclerotic plaque is a key event that leads to atherothrombosis. Because thrombus is induced by chemical or physical injury of normal arteries in most animal mo...
Necrotising enterocolitis (NEC) has a complex pathophysiology but the common end-point is ischaemia reperfusion injury (IRI) and intestinal necrosis. We have previously reported that RIC significantly reduces the intestinal injury in a rat model of NEC.
Conclusions: Neutrophils are a source of TF and are implicated in direct activation of the coagulation cascade in the early phases of sepsis in the monkey. These results give important information for the treatment of sepsis. (Surgery 2000;127:209-16.) 展开 关键词:...
This model emphasizes the importance of specific cellular receptors for the coagulation proteins. Thus, cells with similar phosphatidylserine content can play very different roles in hemostasis depending on their complement of surface receptors. We propose that coagulation occurs not as a "cascade", but...
Ischemic stroke (IS) is the most recorded case of stroke that is caused by decreased blood flow to the brain. Nowadays, therapeutical agents for IS are limited and they have not shown maximum clinical results. Therefore, the exploration of new candidates