Gubhaju, L & Black, MJ. (2005). The baboon as a good model for studies of human kidney development. Pediatr Res, Vol. 58, No. 2005), pp. 505-509, 0031-3998 (Print)Gubhaju L, Black MJ. The baboon as a good model for studies of human kidney development. Pediatr Res. 2005;58:...
Because of the improved survival of premature neonates in recent years, it is important to investigate the effects of premature delivery on the kidney, in which nephrogenesis is still ongoing during the third trimester. Hence, an appropriate animal model that is similar to humans is essential. Th...
When transcription profiles of kidney organoids were compared to human fetal tissues, they showed highest congruence with first trimester human kidney. Furthermore, the proximal tubules endocytose dextran and differentially apoptose in response to cisplatin, a nephrotoxicant. Such kidney organoids ...
Here we generate inherited super-anaemic mice (ISAM) as a mouse model of adult-onset anaemia caused by erythropoietin deficiency. ISAM express erythropoietin in the liver but lack erythropoietin production in the kidney. Around weaning age, when the major erythropoietin-producing organ switches from ...
Hypertension, the chronic elevation of blood pressure, is a complex disease and risk factor for the development of many fatal secondary pathologies, including cardiovascular disease, heart failure, chronic kidney disease, and atherosclerosis. While many gains have been made in basic research using tradi...
Maintenance of the notochord also depends on the function of the peri-notochordal sheath cell epithelium. Excess secretion of collagen proteins, such as those in morphants of the polycystic kidney genespkd1a/bandpkd2, causes dorsal overbending of the notochord [74,75]. Pioneering work in zebrafis...
2). We observed strong and specific hCD147 protein staining across all tissues assayed (lung, 2A; liver, 2B; intestine, 2C; heart, 2D; brain, 2E; spleen, 2F; kidney, 2G; testis, 2H; and trachea, 2I) in knock-in mice compared to WT-NSG mice where no staining was visualized. ...
BA Bauer,S Boedges,CR Cook,EC Bryda,CL Franklin 摘要: The SPRD-Pkdr1 rat model is widely used for the study of human autosomal dominant polycystic kidney disease. This rat model carries the Cy allele of the Pkdr1 gene, which results in polycystic kidney disease. Because the Cy allele is...
Here we describe an ovine model of MKS, with kidney and liver abnormalities, without polydactyly or occipital encephalocoele. Homozygous missense p.(Ile681Asn; Ile687Ser) mutations identified in ovine TMEM67 were pathogenic in zebrafish phenotype rescue assays. Meckelin protein was expressed in ...
Studying surgical injury may provide new insights into mechanisms of kidney regeneration. In rodent models, extrarenal tissues adhere to surgical kidney wound and interfere with healing. We hypothesized that this can be prevented by wrapping injured kidney in a plastic pouch. Adult rats tolerated 5/...