The effect of (-)-carvone was compared with that of the classical calcium channel blocker (CCB) verapamil. In isolated ileal smooth muscle, (-)-carvone did not produce direct contractile or relaxation responses and did not modify electrically elicited contractions or low K+-evoked contractions. ...
mode of action, moa解释-回复 [Mode of action, MOA解释] Mode of action (MOA) refers to the specific way in which a drug or chemical substance produces its effects on the body or target organism. Understanding the MOA of a drug is crucial for both researchersand healthcare professionals as...
and for the treatment of disorders that require sustained antacid action. Sustained release in the stomach is also useful for therapeutic agents that the stomach does not readily absorb, since sustained release prolongs the contact time of the agent in the stomach or in the upper part of the sm...
Gingival hyperplasia induced by calcium-channel blockers: mode of action. Med Hypotheses 1994; 43:115-8.Nyska A, Shemesh M, Tal H, Dayan D. Gingival hyperplasia induced by calcium channel blockers: Mode of action. Med Hypotheses 1994;43:115‑8....
procera (Valerianaceae) and its mode of actionas calcium channel blocker.Journal of Pharmacokinetics and Pharmacodynamics. 2010Vasorelaxant effect of Valeriana edulis ssp procera (Valerianaceae)and its mode of action as calcium channelblocker. ESTRADA-SOTO S,RIVERA-LEYVA J,RAMIREZ-ESPINOSAJ J,et ...
Therapeutic approaches for treatment of EA2 are very limited. Presently, the potassium (K+) channel blocker 4-aminopyridine (4-AP) constitutes the most promising treatment, although its mechanism of action is not understood. Here we show that, in contrast to what is commonly believed, therapeutic...
In other experiments, calcium channel blockers and inhibitors of protein kinases and protein phosphatases reduced or blocked toxin action. Collectively, these data indicated that toxin activates a form of programmed cell death in the host.; Ptr ToxA is a protein that contains the amino acid ...
was found to attenuate the release of calcium (Ca2+) from intracellular stores in the presence of ruthenium red (ryanodine receptor, RyR inhibitor) and extracellular stores via nifedipine (voltage-operated Ca2+ channels, VOCC blocker) and SK&F96365 (receptor-operated Ca2+ channel, ROCC blocker)....
The vasorelaxant effect of evodiamine in rat isolated mesenteric arteries: mode of action. Chiou W F,Chou C J,Shum A Y,Chen C F. European Journal of Pharmacology . 1992Chiou WF; Chou C J; Shum YC;.The vasorelaxant effect of evodiamine in rat isolated mesenteric arteries: mode of action...