Background: We examined whether the apparent association between renal cell carcinoma (RCC) and use of dihydropyridine calcium channel blockers (CCBs) was explained by confounding by indication since hypertension, the main indication for CCBs, is a risk factor for RCC. Methods: Using Danish health...
andintracoronaryorintravenousnicardipinemightresultinareducedincidenceofmyocardialischaemiaduringPTCAThebeneficialeffectofthesedrugscanbeexplainedbyadirectcardioprotectiveeffectorbyanenhancedcollateralflowandhaemodynamicimprovementDuringearlyreperfusioninacutemyocardialinfarction(AMI)administrationofcalciumchannelblockersoragentsthat...
"L-type calcium channel blockers were created to prevent this from happening," said Trebak. "Yet, we found that these drugs also simultaneously cause remodeling and proliferation of VSMCs through another mechanism." To investigate the specific mechanisms by which LCCBs affect VSMCs, Trebak and...
ASH: Calcium Channel Blocker Benefits in ACCOMPLISH Not Explained by Ambulatory BP General nephrology UKidney Staff Tuesday, 02 June 2009 16690 Hits 0 Comments By Crystal Phend, Staff Writer, MedPage TodayPublished: May 12, 2009Reviewed by Zalman S. Agus, MD;...
Calcium channel blockers (CCBs) differ in their ability to penetrate into the brain. Pharmacoepidemiological studies suggest that CCBs as a class may have beneficial effects on the risks and outcomes of some psychiatric and neurological disorders. It is
15. Matsui T, Yamagishi S, Nakamura K, Inoue H: Azelnid- ipine, a new long-acting calcium-channel blocker, inhibits tumor necrosis factor-α−induced monocyte chemoattractant protein-1 expression in endothelial cells. J Int Med Res 2006; 34: 671–675. 16. Nakamura K, Yamagishi S, ...
ceptorsorcalcium-channelblockersmayfacili-(above2cm)oralargeorobstructingstonebur- 32den.Thisprocedurerequiresgeneralanesthesia tatepassageofureteralstones.Ingeneral,stones largerthan10mmieterwillnotpass,andandhospitalizationandcarriesmoreriskofcom- thosesmallerthan5mmwill;stonesfrom5mmplications,includingbleedingand...
This difference may be explained by circadian changes in calcium channel function. Therefore in the present study we documented the effects of calcium channel blockers in perifused rat pineal glands removed in the middle of the light and dark spans (7 and 19 HALO (hours after light onset), ...
(Fig.2a). We also examined the binding activity of other dihydropyridine calcium channel blockers and Fig.1summarizes the results. Nisoldipine but not nitrendipine and nilvadipine significantly suppressed [3H]-DPCPX binding, whereas isradipine and amlodipine exhibited only weak binding to the A2B...
In order to explain the potent antihypertensive activity of the modestly active (IC50 = 3.2 microM) dihydropyrimidine calcium channel blocker 5, we carried out drug metabolism studies in the rat and found 5 is metabolized to compounds 6-10. Two of the metabolites, 6 (IC50 = 16 nM) and 7...