HE of 1 2 week s MMTV —P yMT mice A B 图5 A.12 周 MMTV—PyMT 小 鼠肺转移 图(箭 头部位 为其 中 2 个转移瘤 ) ;B.HE 图(400 X ) F igu r e 5 A . Lu ng metastas es tu mor of 12 weeks MMTV —P yMT mice ;B . HE of l ung metas tases tu mor of 1 2 weeks ...
Here we examined the metabolic effects of high-fat diet (HFD) feeding in female MMTV-PyMT mice, a breast cancer model expressing the polyoma middle T antigen driven by the Mouse Mammary Tumor Virus promoter. Female PyMT and wild type (WT) mice were fed a HFD (55% fat by cal...
乳腺癌 MMTV-PyMT 小鼠通过转基因形式构建,转基因元件包含 the mouse mammary tumor virus (MMTV) 启动子、the Polyoma Virus middle T antigen (PyVT) 编码序列、SV40 polyA 序列。 MMTV-PyMT 转基因雌鼠在 14-16 周龄大概率自发产生乳腺肿瘤,最早成瘤在 5 周龄左右。成瘤后有 80% 左右会发生肺部转移。
AR protein expression was examined in late-stage primary tumors and lung metastases from MMTV-PyMT mice as well as in Met-1 cells by immunohistochemistry (IHC). Sensitivity of Met-1 cells to the AR agonist dihydrotestosterone (DHT) and anti-androgen therapy was examined using cell viability, ...
【Keywords】CLCN3;MMTV-PyMT;Transgenicmice;Breastcancer 中扮演了重要的角色 [1] 。ClC氯通道(ClCchloride channel)是一类电压门控性氯通道,目前在哺乳动 物细胞中已发现九种家族成员,其中ClC-3是备受 离子通道如K + 、Cl - 和Na + 通道的高表达促进 ...
Using recombinant GT198 protein as an antigen, we vaccinated MMTV-PyMT mice and found that the GT198 vaccine delayed mouse tumor growth and reduced lung metastasis. The antitumor effects were linearly correlated with vaccinated mouse serum titers of GT198 antibody, which recognized cell surface GT...
1、CLCN3MMTVPyMT 转基因小鼠杂交群体的建立及鉴定邓璐璐;李琴;吴慧;毛建文;徐彬【摘要】ToaCLCN3/MMTV-PyMTmouse moel of spontaneous breast tumor ClC-3.Metho CLCN3 were crosse MMTV-PyMT spon-taneous mammary tumor moel mice.The wasbyPCR.Theofwasetec-tebyanWesternCLCN3anMMTV- PyMTwerebreanCLCN3/...
The tumor biological feature was obvious in MMTV-PyMT mice, palpable Mast adenoma occur in 9 week old and pulmonary metastasis was occur in 11 weeks old.Number and size of tumors increased when the mice grow up. Conclusions The MMTV-PyMT transgenic mouse model was well kept and bred, bre...
AR protein expression was examined in late-stage primary tumors and lung metastases from MMTV-PyMT mice as well as in Met-1 cells by immunohistochemistry (IHC). Sensitivity of Met-1 cells to the AR agonist dihydrotestosterone (DHT) and anti-androgen therapy was examined using cell viability, ...
We used female MMTV-PyMT transgenic mice to investigate the effect of murine THPO-ASO treatment on blood platelet count, plasma TPO levels, and progression of breast cancer. Hemizygous MMTV-PyMT mice spontaneously developed ultimately fatal metastatic breast cancer in mammary glands, with early microsc...