中文名称:NEDD8活化酶抑制剂(MLN4924) 英文名称:NEDD8-activating enzyme inhibitor 产品规格:1mL(10mM)|1mg|5mg|10mg|50mg|100mg|200mg MLN4924是一种有效的选择性NEDD8活化酶(NEDD8-activating enzyme,NAE)抑制剂,IC50为4.7nM。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途! CAS号:905579-51-3 别名...
NEDD8活化酶抑制剂(MLN4924) 英文名称:NEDD8-activating enzyme inhibitor产品规格:1mL(10mM)|1mg|5mg|10mg|50mg|100mg|200mg发货周期:1～3天产品价格:询价本产品仅可用于科研实验,严禁用于其他非科研用途!MLN4924是一种有效的选择性NEDD8活化酶(NEDD8-activating enzyme,NAE)抑制剂,IC50为4.7nM。注:本品仅可...
引用本文: 李蒙,张荔,赵伟丽等.氯化两面针碱对类泛素化修饰抑制剂MLN4924介导肺癌耐药的作用与机制研究[J].上海中医药大学学报,2023,37(04):22-27. (LI Meng,ZHANG Li,ZHAO Weili,et al.Study on effect and mechanism of nitidine c...
Pevonedistat (MLN4924) MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme ( NAE ) with IC50 of 4 nM. In vitro MLN4924 is structurally related to adenosine 59-monophosphate (AMP)—a tight binding product of the NAE reaction. MLN4924 (3 μM) selectively inhibits NAE in HCT-11...
英文名称:NEDD8-activating enzyme inhibitor 产品货号:M00007 产品规格:1mL(10mM)|1mg|5mg|10mg|50mg|100mg|200mg MLN4924是一种有效的选择性NEDD8活化酶(NEDD8-activating enzyme,NAE)抑制剂,IC50为4.7nM。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!
上海复旦大学学者在PNAS杂志上发表题为The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice的研究论文,报道了脑卒中后梗死周围皮层中性粒细胞中拟素化通路上调,使用拟素化抑制剂MLN4924可通过上调NF1基因表达减少NEDD...
To this end, we evaluated MLN4924, an NAE inhibitor which prevents the neddylation and activation of cullin-RING ubiquitin ligases, in MCL pre-clinical models. A panel of MCL cell lines and primary tumor cells isolated from MCL patients were exposed to escalating doses of MLN4924 alone or in...
MLN4924参考文献：[1]. Soucy TA, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009 Apr 9;458(7239):732-6.[2]. F S Wolenski, et al. The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis. Cell Death ...
MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM). ChemeGen 作为优秀的抑制剂、激动剂及新型生命科学试剂的供应商,致力于为广大科研、商业实验室的科学
[2]. Soucy TA, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009 Apr 9;458(7239):732-6.