ENL(Enhancer of nuclear factor-κB ligand)融合基因是一种常见的MLL融合基因,它与MLL基因的融合会导致白血病的发生。 ENL融合基因的白血病类型主要集中在急性髓系白血病(AML)和急性淋巴细胞白血病(ALL)两种。其中,AML占比较高,约为80%。这种白血病的治疗效果受到多种因素影响,如患者年龄、病情严重程度、融合基因类型...
ChemicalBook 致力于为化学行业用户提供MLL-ENL oncoprotein的性质、化学式、分子式、比重、密度,同时也包括MLL-ENL oncoprotein的沸点、熔点、MSDS、用途、作用、毒性、价格、生产厂家、用途、上游原料、下游产品等信息。
MLL-ENL..Mixed-lineage leukemia (MLL) fusion proteins are associated with a unique class of leukemia that is
MLL-ENL cooperates with SCF to transform primary avian multipotent cells. EMBO J . 2002;21:4297–4306.Schulte, C.E., von Lindern, M., Steinlein, P., Beug, H., and Wiedemann, L.M. (2002). MLL-ENL cooperates with SCF to transform primary avian multipo- tent cells. EMBO J. 21...
德国兰根大学Robert K. Slany揭示了MLL-ENL融合蛋白抑制控制基因表达的PRC,从而促进造血干细胞的分化。 转录延长的发生是造成白血病的主要原因,而MLL是造成转录延长的关键。此项研究表明,MLL-ENL融合蛋白同样可以抑制调停基因表达的PRC的活性,从而促进造血干细胞的分化。
OBJECTIVE: The aim of this study was to better understand how mixed lineage leukemia (MLL) fusion proteins deregulate the expression of genes critical for leukemia. MATERIALS AND METHODS: The transforming domain of one of the most common MLL fusion partners, AF9, was immunopurified after ...
急淋B MLL/ENL融合基因阳性 预后如何(男,1岁3个月) 分析及建议: 请把整张病理报告以及骨髓穿刺报告拍照上传,以便专业分析,最好还是化疗后骨髓移植,边化边评估吧,如果血象能很快改善,还是很有希望的,总体来说急淋b比急淋t好治些,嗯,应该说是见一步走一步,如果化疗很好,可以暂时不用考虑骨髓移植,好的,你的...
MLL-ENL cooperates with SCF to transform primary avian multipotent cells Schulte,E C.,V Lindern,... - 《Embo Journal》 被引量: 12发表: 2002年 Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. During vertebrate retinogenesis, seven classes of cells are ...
百度试题 结果1 题目下列哪种是M2b型白血病的特异性基因 A. PML-RARα B. MLL-ENL C. CBFB-MYH11 D. bcr-abl E. AML1 相关知识点: 试题来源: 解析 E 反馈 收藏
Using a conditional mouse strain, we demonstrated that Mef2c deficiency does not impair the establishment or maintenance of LSCs generated in vitro by MLL/ENL fusion proteins; however, its loss led to compromised homing and invasiveness of the tumor cells. Mef2c-dependent targets included several ...