Evolution of complex characters typically involves preadaptation, radical mutational innovation, and different selective forces acting in succession [3,6,10]. Here I paint an integrated picture of how the nucleus, sex, and the eukaryotic cell cycle originated and congealed into a novel, unified, a...
and different selective forces acting in succession [3,6,10]. Here I paint an integrated picture of how the nucleus, sex, and the eukaryotic cell cycle originated and congealed into a novel, unified, and very conservative cellular lifestyle during later stages of the conversion of a bacterium...
What the contribution of cell division is during natural Td remains an open question, and the extent of mechanistic variations among different Td events, even within a given organism, is unclear. Our lab has been taking advantage of C. elegans to study natural Td in vivo at single-cell ...
In this review, current antimitotic agents are summarized with particular emphasis on the evaluation of their clinical efficacy as well as their limitations. In addition, we discuss the basis behind the lack of activity of these inhibitors in human trials and the potential and future directions of...
In the case of the c3c4 double mutant, slight blebbing was detected, which was not changed dramatically by the DQ treatment. The appearance of nuclear blebbing and interphase chromatin condensation in the different genotypes after drug treatment is summarized in Table 1. Figure 1. The effects of...
In this review, current antimitotic agents are summarized with particular emphasis on the evaluation of their clinical efficacy as well as their limitations. In addition, we discuss the basis behind the lack of activity of these inhibitors in human trials and the potential and future directions of...