Accurate chromosome segregation during both mitosis and meiosis is governed by an intricate and synchronised cascade of events. These are controlled by the molecular networks that ensure the proper assembly of sister deoxyribonucleic acid (DNA) molecules produced during DNA replication, followed by the ...
Schematic illustration of the roles of Cdk1 during the G2-M transition in mitosis and in the germinal vesicle breakdown that occurs during resumption of meiosis. (A) Cdk1 kinase is activated and promotes the phosphorylation of mitotic phosphoproteins at the G2-M transition in ...
Meiosis and Amitosis Mitotic division is the method of nuclear division of the somatic (body) cells, as distinguished from the gametes, or sex cells (eggs and sperm). In sexual reproduction, i.e., by the union of two gametes, the complex process of meiosis takes place, which produces cel...
Coils up into chromosomes Chromatin to chromosomes illustration: Chromatin Coils up into chromosomes Duplicates itself Replicated CHROMOSOME CHROMOSOME Why does DNA need to change from chromatin to chromosome? More efficient division All somatic (body) cells in an organism have the same kind and number ...
length depending upon the cell's function, the cell cycle for all cells can be described in five steps. The first three steps where the cell grows, matures, and carries out its life function are collectively calledinterphase, followed bymitosis, andcytokinesis. Refer to the i...
The conserved kineto- chore protein shugoshin protects centromeric cohesion during meiosis. Nature 2004; 427:510-517. 6 Salic A, Waters JC, Mitchison TJ. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell 2004; 118:567-578. 7 McGuinness BE,...
that vertebrate Sgo plays a similar role in centromeric cohesion in mitosis as fly and yeast homologs perform in meiosis. Intriguingly, vertebrate Sgo also links cohesion of sister Kts and regulation of Kt-MT interactions, thus integrating two aspects critical for proper chromosome segregation in ...