Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches. Chem Rev. 2013;113:6816–63. CentralBass, P.D.; Gubler, D.A.; Judd, T.C.; Williams, R.M. Mitomycinoid alkaloids: Mechanism of action, biosynthesis, total syntheses, and synthetic approaches...
Mitomycin C (MMC) is the best investigated subtype. It serves as a prototype for drugs with bioreductive alkylation, which is a unique feature of this class. MMC is mainly active under anaerobic circumstances. The pharmacokinetics are linear in a two-compartment model. The main toxicities of ...
The unique mechanism of action and clinical success of mitomycin, coupled to its high toxicity, prompted the preparation of a large number of synthetic analogs, many of which belong to the mitosene group and have the general structure 6.13. Some simpler indolequinone derivatives, such as EO4 an...
Mitomycin C is a quinone-based antitumor antibiotic that crosslinks the complementary strands of the DNA double helix with exquisite base- and regioselectivity for the N2 of guanine. (1) It first entered clinical trials in 1958 has been employed since 1974 in combination chemotherapy treatments (2...
Antibiotics A to;Antibiotics by Application;AntibioticsAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Cell Culture;Chemical Structure Class;Culture;Mechanism of Action;Reagents and Supplements;Stem Cell Isolation;AziridinesAntibiotics;Core Bioreagents;Interferes with DNA Synthesis;Research ...
The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2 /cyclin B Cancer Res., 52 (1992), pp. 1823-1829 View in ScopusGoogle Scholar Verweij and Pinedo, 1990 J. Verweij, H.M. Pinedo Mitomycin C: mechanism of action, usefulness and limitati...
We report the first case in the world literature of laryngeal carcinoma in a non-smoking adult, which may have been induced by topical mitomycin C application to a glottic web. We discuss the mechanism of action of this drug, and we advise caution on its use for benign laryngeal ...
mitomycin C and hyperthermia-induced apoptosis, whereas cells expressing a phospho-mimic Bcl- xL are sensitive to the combinatorial treatment-induced apoptosis, indicating that phosphorylation at Ser-62 is a key regulatory mechanism for antagonizing anti-apoptotic function in the combinatorial treatment. ...
The unique mechanism of action and clinical success of mitomycin, coupled to its high toxicity, prompted the preparation of a large number of synthetic analogs, many of which belong to the mitosene group and have the general structure 6.13. Some simpler indolequinone derivatives, such as EO4 an...
MITOMYCIN c, an anti-tumour agent from culture filtrates of Streptomyces caespitosus, is effective against both Gram-positive and negative bacteria, and is bacteriocidal to growing and non-growing bacteria1. It is an extremely potent inhibitor of growth