However, investigations delving into the correlation between mitochondrialrelated genes (MRGs) and the prognosis and metastasis of BC are still infrequent. Methods: Utilizing data from the TCGA database, we employed the "limma" R package for differential expression analysis. Subsequen...
The goal of this study was to develop a novel prognostic model based on Mitochondrial-related genes (MRGs). We first analyzed the somatic alterations profiles of MRGs in patients with LGG and found that somatic alterations were common in LGG and correlated with prognosis. Using RNA-seq data ...
Effects of mutations in mitochondrial dynamics-related genes on the mitochondrial response to ultraviolet C radiation in developing Caenorhabditis elegans. Bess AS,Leung MC,Ryde IT,et al. Worm . 2013Bess AS, Leung MCK, Ryde IT, Rooney JP, Hinton DE, Meyer JN. Effects of mutations in ...
BMC Genomics (2015) 16:968 DOI 10.1186/s12864-015-2121-0 RESEARCH ARTICLE Open Access Genes related to mitochondrial functions are differentially expressed in phosphine- resistant and -susceptible Tribolium castaneum Brenda Oppert1*, Raul N. C. Guedes2, Michael J. Aikins3, Lin...
Among these genes, Hadhb, Cpt1a, Mrpl12, and Mrps7 were confirmed both in a POI model and in human granulosa cells (GCs), where they were found to accumulate in GCs and theca cells. Immune analysis revealed variations in macrophages, monocytes, and 15 other immune cell types between the ...
It has been hypothesized that part of the maternal bias may be due to the unequal inheritance of COX genes; while most subunits are encoded by nuclear DNA, three are inherited from the mother's mtDNA [43]. Other mitochondrial genes have also been linked to an increased risk of developing ...
Given all of the above, our aim in this study was to investigate the effects of Ube3a deletion on the expression of mitochondrial-related genes, by also utilizing TNFα stimulation as a means to further push mitochondrial-related pathways. For this, we utilized mouse embryonic fibroblasts (MEFs...
Mutations in mitochondrial tRNA genes: non-linkage with syndromes of Wolfram and chronic progressive external ophthalmoplegia. We have recently identified a point mutation in the mitochondrially encoded tRNA(Leu(UUR)) gene which associates with a combination of type II diabetes mel... van den Ou...
Alterations in mitochondrial homeostasis have been implicated in the etiology of Parkinson disease (PD) as demonstrated by human tissue studies, cell culture and in vivo genetic and toxin models. Mutations in the genes encoding PTEN-induced kinase 1 (PINK1), Omi/HtrA2 and parkin contribute to rar...
(2-ΔΔCT) method was applied to quantify mRNA expression usingGAPDHas the reference gene. After controlling for age, sex, BMI, and medication status using linear regression models, expression of the inflammasome (NLRC4andNLRP3) and the ER stress (XBP1u, XBP1s, andATF4) genes was found ...