Functional clustering of a total of 146 genes in RTT identified key biological pathways related to mitochondrial function and organization, cellular ubiquitination and proteosome degradation, RNA processing, and chromatin folding. Our microarray data reveal an overexpression of genes involved in ATP ...
To gather more information about whether the expression of mitochondria-associated genes in the PFC of mCRS mice can be related to mice behavioral profiles, we applied a model selection analysis of gene expression that considers the individual differences in stress and behavioral responses of the test...
The mitochondrial activity depends on the integrity ofmitochondrial biogenesis, including maintenance and survival of pre-existing mitochondrial function.Mitochondrial biogenesisincludes membranebiosynthesis, replication of mtDNA, synthesis of nDNA and mtDNA-encoded proteins, and transport of nuclear-encoded prote...
PriyankarPal, ...Prabir KumarMukhopadhyay, inGenes & Diseases, 2023 Effect on mitochondrial fission The dynamin-relatedprotein 1(Drp1)/mitochondrial fission factor(Mff) signaling pathway has a pivotal role inmitochondrial fission. An affiliation is created between mitochondria and endoplasmic reticul...
prevents oxidative stress-induced cell death. Diminished glycolytic function also reduces the utilization of TCA cycle-related enzymes and FDX1-related genes in mitochondria, allowing tumor cells in high-copper environments to resist cuproptosis [196,197]. In addition, local hypoxic, acidic, and low...
which directly regulates cellular function [135]. Age-related alterations in fatty acid content and decreased mitochondrial function have been identified in testicular mitochondria, may have an effect on the fluidity and activity of the mitochondrial complex, and are associated with a rise in the form...
hystrix[14]. The RNA editing sites occurred in almost all protein-coding genes, indicating that the mitochondrial gene ofF. suspensamay have an important effect on the function of RNA editing sites. Codon bias is the combined result of natural selection, species mutation, and genetic drift. The...
We analyzed the organization and function of mitochondrial DNA in a stable human cell line (ECV304, which is also known as T-24) containing mitochondria tagged with the yellow fluorescent protein. Mitochondrial DNA is organized in ~475 discrete foci cont
As a general rule, mutations in structural genes are not associated with RRFs. Mitochondrial diseases are highly heterogeneous with varying clinical features caused by impaired function of the mitochondrial respiratory chain. The underlying cause can be gene mutations in nuclear or mitochondrial mtDNA, ...
(Ivitrogen, USA) according to the manufacturer’s instructions. The cDNA was synthesized from 5 μg of RNA using Maxime RT PreMix Kit (iNtRON Biotechnology, Korea). The expression of mitophagy-related genes was measured by qRT-PCR using the 2 × Rotor-Gene SYBR Green PCR Master Mix (...