样本:Mitochondrial Rho GTPase 1 ELISA Kit 检测方法:详见说明书 应用:ELISA 货号:BK-F99763 是否进口:是 Mitochondrial Rho GTPase 1 ELISA Kit的详细说明书 检测范围: 使用:本试剂仅供科研使用 保存:2-8℃ 有效期:6个月 检测方法:ELISA 产品性状:96T/48T,盒装液体 ...
[CV(%) = SD/mean x100].Storage Stability: The loss activity rate of this kit is less than 8% within the expiration date under appropriate storage condition.Cat.No: MBS
dMiro;Gem1;hMiro;Miro-1;Miro-2;Mitochondrial Rho GTPase 1-like;RHOT1 (Ras homolog family member T1);RHOT2;Rhot1;Rhot2; Historical Background The Ras superfamily family of small GTPases consists of GTP binding-dependent molecular switches with diverse cellular functions. Two isoforms of an ...
Drp1: dynamin-related protein 1; MFN1/2: mitogenic protein 1/2; Opa1: optic atrophy protein 1; Fis1: protein fission 1; Mff: mitochondrial fission factor, PINK: PTEN-induced kinase 1, Miro: mitochondrial rho GTPase Full size image Fig. 2 Key proteins and signaling pathways orchestrate ...
The roles of miR-27-3p and its target gene Miro1 (also known as Rhot1, encoding mitochondrial rho GTPase 1) and relevant pathways were predicted and assessed in vitro and in vivo using specific miRNA mimic, miRNA inhibitor, miRNA antagomir and siRNA. Results miR-27-3p was highly expressed...
Mitochondria dynamically alter their subcellular localization during cell movement, although the underlying mechanisms remain largely elusive. The small GTPase Arf6 and its signaling pathway involving AMAP1 promote cell invasion via integrin recycling. H
Miro1, a Rho GTPase, regulates the formation of actin-based intercellular structures, and its pharmacological and genetic suppression correlates with a lower rate of mitochondrial transfer and therefore loss of metabolic and functional benefits in neural stem cells (NSC) and primary cortical neurons [...
MFF shares similar localization and function with FIS1, recruiting high-oligomeric forms of DRP1 and stimulating its GTPase activity [92]. Experimental evidence shows that overexpression of MFF exacerbates mitochondrial fission, while its absence does not significantly affect mitochondrial dynamics. The ...
mitochondrial Rho GTPasemiro-1caused epidermal mitochondria to become straight and aligned, losing their typical interconnected network structure (Fig.3b, Supplementary Fig.5a). Moreover, inmiro-1null mutants, WIMF is tightly restricted to the injury site (Fig.3b, d), indicatingmiro-1is involved...
However, the same Rho GTPase signaling pathways operating in neuronal cells may act in a different way depending on the cell type. Indeed, observations in macrophages indicate that the blockage of Arp2/3 results in a decrease of TNTs formation [104]. Moreover, pathways converging on Arp2/3...