paternally inherited, is used in an analogous way to trace the agnate lineage.) This is accomplished on human mitochondrial DNA by sequencing one or more of the hypervariable control regions (HVR1 or HVR2) of the mitochondrial DNA,
(mtDNA) from different Oenothera berteriana and Oenothera odorata bastards are compared and the identity of mtDNA in hybrid forms with different com binations of nuclear, Filastid, and mitochondrial genom es has been determined, nheritance of m tDNA in these hybrids follows the pattern predicted ...
The inheritance of mitochondrial DNA (mtDNA) is predominantly uniparental in most sexual eukaryotes. In this study, we examined the mitochondrial inheritance pattern of Cryptococcus gattii, a basidiomycetous yeast responsible for the recent and ongoing outbreak of cryptococcal infections in the US Pacifi...
Normal mitochondrial function relies on two types of inheritance: maternal inheritance of circular mtDNA sequences and biparental inheritance of nuclear DNA (nDNA) that has over 1000 genes for mitochondrial homeostasis. Consequently, mitochondrial dysfunction because of mtDNA defects or nDNA mutations can...
This study shows that a very high rate of mutation rapidly produces new repeat lengths (new haplotypes) for this mitochondrial variable number tandem repeat. A maternal inheritance pattern is also demonstrated for this repeat sequence, while the high mutation rate causes some offspring to exhibit ...
is a commonly occurring form of inheritable neurological disorder, with autosomal dominant being the most common inheritance pattern, although autosomal recessive and X-linked subtypes also exist.160 Research efforts have focused on identifying disease-modifying therapies for the most frequently encountered ...
Mitochondria are passed on exclusively from the ovum to all the offspring of both sexes, a novel pattern of inheritance. Owing to the critical role of mitochondria in cellular energy metabolism, deletions or point mutations of the mitochondrial DNA often cause progressive SNHL and a variety of ...
Transmission was uniparental; the plasmodia that were formed carried mtDNA with the restriction pattern of only one of the two parental types. Since diploid zygotes develop into plasmodia by repeated mitotic cycles in the absence of cell division, it is clear that this uniparental transmission of ...
Barrell BG, Anderson S, Bankier AT et al. (1980) Different pattern of codon recognition by mammalian mitochondrial tRNAs. Proc Natl Acad Sci USA 77: 3164–3166 ArticlePubMedCASGoogle Scholar Berk AJ, Clayton DA (1974) Mechanism of mitochondrial DNA replication in mouse L-cells: asynchronous re...
their mtDNA is never transmitted to the offspring. This pattern of mtDNA inheritance is well known as “maternal inheritance.” However, how the paternal mitochondria and mtDNA are eliminated from the cytoplasm of gametes or zygotes remains an enigma. Recently, a variety of mechanisms, including ...