Reprints and permissions information is available atwww.nature.com/reprints. Rights and permissions Reprints and permissions About this article Cite this article Friedman, J., Nunnari, J. Mitochondrial form and function.Nature505, 335–343 (2014). https://doi.org/10.1038/nature12985 ...
Subcellular specialization of mitochondrial form and function in skeletal muscle cells. Front. Cell Dev. Biol. 9, 757305 (2021). Article PubMed PubMed Central Google Scholar Cogswell, A. M., Stevens, R. J. & Hood, D. A. Properties of skeletal muscle mitochondria isolated from sub...
We analyzed the organization and function of mitochondrial DNA in a stable human cell line (ECV304, which is also known as T-24) containing mitochondria tagged with the yellow fluorescent protein. Mitochondrial DNA is organized in ~475 discrete foci cont
Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead to dysfunction and cell death in aging and age-related disorders. Recent research suggests that mitochondrial dysfunction is closely
possesses a 90 bp AT-rich insert (Figure 1: black vertical bar) with a potential to form a triple hairpin structure (Figure 1, black box). Similar insertions have been found in nad2 and nad5 of Axinella corrugata (see below). Considering the fact that they do not cause frameshifts ...
(a)Matrix proteins typically have N-terminal pre-sequences that form amphipathic helices (1). These pre-sequences bind to receptors on the surface of mitochondria (2) and direct the precursor protein across the outer (3) and inner (4) membrane. Following translocation, the pre-sequences are...
When multi-domain Bcl-2 family members such as Bax and Bak (see Section 2.3) are activated, they may form oligomers and insert into the outer membrane. Following mitochondrial remodelling, they form channels to allow the passage of proteins such as cytochrome c to the cytosol (Donovan and ...
(ADP) and inorganic phosphate when protons re-enter the mitochondrial matrix through the complex V enzyme. However, either by accident or by design, the process of ETC is not perfect. Leakage of electrons at complex I and complex III leads to partial reduction of oxygen to form superoxide (...
and tumour cell growth as important messengers. EV-mediated mitochondrial transfer was found in multiple tissues as part of essential cellular bioprocesses. Previous studies suggested that astrocytes secrete EVs to regulate neuronal function, synaptic formation, and maintenance [25]. Hayakawa et al. foun...
During sprouting angiogenesis, an individual endothelial tip cell grows out from a pre-existing vascular network and guides following and proliferating stalk cells to form a new vessel. Metabolic pathways such as glycolysis and mitochondrial respiration as the major sources of adenosine 5′-triphosphate...