The book begins with a general overview of Warburg Hypothesis, mitochondrial structure and function, and then outline more specifically the metabolic and molecular alterations in mitochondria that are associated with human cancer and their clinical implications. An emphasis is also placed on mtDNA ...
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the “phosphocreatine circuit” for cellular energy homeostasis Biochem. J., 281 (Pt 1) (1992), pp. 21-40 CrossrefView in ScopusGoogle Scholar [10] Y. Capetan...
Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations....
FUNCTION AND FINE-STRUCTURE IN PROTISTA: 3. THE ROLE OF MITOCHONDRIA IN SOME PROTOZOAN LIFE CYCLESFirst page of articledoi:10.1111/j.1095-8312.1963.tb00895.xKeith VickermanDepartment of Zoology and Comparative Anatomy, University College London;...
J. Mitochondrial iron–sulfur clusters: structure, function, and an emerging role in vascular biology. Redox Biol. 47, 102164 (2021). Article CAS PubMed PubMed Central Google Scholar Rydstrom, J. Mitochondrial NADPH, transhydrogenase and disease. Biochim. Biophys. Acta 1757, 721–726 (2006)...
The structure and the functions of ER-mitochondria interface are regulated by several proteins located in ER and/or mitochondrial membranes, particularly at the level of the so called mitochondria associated membranes (MAM; [21]). Here, key steps of processes, such as modulation of intracellular ...
The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan. We found that the e1370 mutation alters aerobic
Mitochondria: structure and function The mitochondrion exhibits unique architecture, comprising of an inner membrane encased by an outer membrane dividing it into two distinct compartments [95]. The outer membrane, separating the intermembranous space from the cytosol, is permeable to most sorts of ion...
Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis Xinxiu Liang,Yuanqing Fu,Wen-ting Cao,Zhihong Wang…Article:49 Download PDF(2823KB)View Article Review The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders ...
The structure and functions of cancer cells differ compared with normal cells5, 16. Hexokinase, the BCL-2 family, electron redox chain, voltage-dependent anion channel/adenine nucleotide translocase (VDAC/ANT) complex and mitochondrial DNA in the mitochondria all could represent targets for antitumor...