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The FinnGen dataset is also characterized by its high-quality data curation and stringent quality control measures, ensuring its accuracy and reproducibility for research purposes. This dataset has been made available to researchers worldwide for the purpose of enhancing understanding of the genetics ...
Please note that I am adding information from haplogroup projects at Family Tree DNA. This information is self-reported and should only be utilized with confidence after confirming the accuracy of the information. Please note that in earlier papers and projects, not all results may have been test...
However, whether mitochondrial DNA mutations are involved in HM remains unexplored. Here, we performed the first large-scale whole-mitochondrial genome study in 9613 HM cases and 9606 control subjects of Han Chinese ancestry for identifying HM-associated mitochondrial variants. The single-variant ...
tumour samples carrying missense mutations in DNA repair oncogenes38,39were more likely to harbour tumour-specific NUMTs than the remaining tumours (77.7% versus 63.1%, Fisher’s exact testP = 5.05 × 10−6, 95% confidence interval 1.44–2.68, odds ratio = 1.95) (Fig.5fand...
This thorough characterization achieved an average coverage depth of 300X, ensuring high reliability and accuracy in the mitogenomic data obtained. The construction of a maximum likelihood (ML) phylogenetic tree based on concatenated coding sequences (CDS) of the 13 PCGs unveiled the intricate genetic...
Mitochondria are essential organelles, found within eukaryotic cells, which contain their own DNA. Mitochondrial DNA (mtDNA) has traditionally been used in population genetic and biogeographic studies as a maternally-inherited and evolutionary-neutral ge
Dr Gorman has full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Ng, Dallabona, Gilberti, Prokisch, Turnbull, Donnini, Taylor, Gorman. Acquisition, analysis, or interpretation of ...
Estimating the Time to Most Recent Common Ancestry (TMRCA) of C. harengus, and its intraspecific subclades was performed using a Bayesian relaxed clock method implemented in BEAST v.1.6 [46]. The all genes concatenated dataset was used, with two additional aligned sequences from each of the ...
(DAMPs), which include mitochondrial DNA (mtDNA), ATP, cardiolipin and formyl peptides53. Owing to the bacterial ancestry of mitochondria, mtDAMPs are recognized by the same set of innate immune receptors (e.g., Toll-like receptor 9), which detect bacterial infections and trigger an ...