with the majority (85.8%,n = 812) being enriched in introns versus exons (P = 0.01, permutation test) (Fig.3gand Supplementary Figs.1–3). No common or rare NUMTs (F > 0.1%) were found in the coding DNA sequences (CDS) (P = 0.039 permutation test), and none ...
Mitochondrial DNA point mutations Current mitochondrial disease therapeutic agents Challenges and future perspectives Data availability statement Acknowledgments Supplemental information ReferencesShow full outline Cited by (12) Figures (5) Tables (1) Table 1 Extras (3) Download all Document S1. Supplemen...
Mitochondrial DNA (mtDNA) variants influence the risk of late-onset human diseases, but the reasons for this are poorly understood. Undertaking a hypothesis-free analysis of 5,689 blood-derived biomarkers with mtDNA variants in 16,220 healthy donors, here we show that variants defining mtDNA haplo...
Differences in ancestry and timing of the species’ radiations can be related to the different biogeography of the two regions. This implies that the historical imprint on adaptive radiations could be predicted on the basis of the attributes of ancestors and biogeographical context. CAS-3 JCR-Q1...
Polymorphism parameters such as number of polymorphic sites, haplotype, and nucleotide diversity were evaluated in DnaSP v.5.10.01 (Librado & Rozas, 2009). MEGA X was used to estimate mean p-distances between haplogroups and subspecies and to calculate a phylogenetic maximum likelihood (ML) tree...
Death-associated protein kinase (DAPK) 2 is a serine/threonine kinase that belongs to the DAPK family. Although it shows significant structural differences from DAPK1, the founding member of this protein family, DAPK2 is also thought to be a putative tum
(n = 330) assigned to either of the two clusters based on individual ancestry coefficient threshold ofq\(\ge \)0.9. The remaining individuals exhibited mixed ancestry (n = 66, 17.7%), and are hereafter referred to as Admixed (Table2). Cluster assignment is broadly concordant with...
After grouping studies by ancestry, risk estimates were potentiated for the comparisons of the 2nd and 3rd tertiles with the 1st tertile of mtDNA copy number in populations of both White and Asian ancestries, especially in the former (OR = 1.83 and 2.97; P = 0.081 and 0.045, ...
Mitochondrial DNA has been widely used as a marker in population genetic, biogeographic, phylogenetic and DNA barcoding studies49. Due to their relative rapid coalescence, one should be able to distinguish reciprocally monophyletic groups even when analyses of nuclear markers fail to do so. However,...
Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription. J Biol Chem 2002; 277: 41817–41826. 34. Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nature reviews. Drug Discov 2013; 12: 931–947. 35. Rassool FV, Gaymes TJ, ...