Fink (2002) Photodynamic therapy of DNA mismatch repair-deficient and -proficient tumour cells. Br. J. Cancer 86, 1130-1135.Schwarz VA, Hornung R, Fedier A, Walt H, Haller U, Fink D (2002) Photodynamic therapy of DNA mismatch repair-deficient and -proficient tumour cells. Br J Cancer ...
Although the great majority of the tumour cells were MMR proficient, those MMR-deficient cells might have been selected during the establish- ment of the tumour cell line. Another possible explanation is that at least part of the methylations might have been acquired in vitro during cell ...
key genes: mutL homologue 1 (MLH1), postmeiotic segregation increased 2 (PMS2), mutS homologue 2 (MSH2), and mutS 6 (MSH6). If one or more proteins are not expressed or are dysfunctional, the status is called dMMR; otherwise, the status is considered mismatch repair proficient (pMMR)....
Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress Background: DNA mismatch repair deficiency is present in a significant proportion of a number of solid tumours and is associated with distinct clinica...
Tumours with low instability included one CRC, two endometrial tumours, three urothelial tumours, one ovary tumour, Abbreviations: CRC ¼ colorectal cancer; dMMR ¼ defective DNA mismatch pMMR ¼ proficient DNA mismatch repair. Bold faced numbers correspond to global effectives. dMMR corresponds...
Mutations in the human mismatch repair (MMR) genes are associated with hereditary non-polyposis colorectal cancer as well as other sporadic cancers. MMR gene mutations have been implicated in the resistance of human tumours to cisplatin and several tumour-derived MMR-deficient cells show cisplatin res...
p53 signalling and DNA mismatch repair (MMR) are known to be deranged in CRC and have been reported as potential molecular targets for the anti-tumour activity of NSAIDs. Furthermore, both p53 and MMR dysfunction have been shown to confer resistance to chemotherapeutic agents. Here, we set ...
Article: Reduction of spontaneous mutagenesis in mismatch repair-deficient and proficient cells by dietary antioxidants
Mismatch repair deficient (dMMR) gastro-oesophageal adenocarcinomas (GOAs) show better outcomes than their MMR-proficient counterparts and high immunotherapy sensitivity. The hypermutator-phenotype of dMMR tumours theoretically enables high evolvability
Recommendation: Tumour mismatch repair (MMR) testing Immunohistochemistry (IHC) tests for MMR proteins or PCR tests for microsatellite instability (MSI) in the metastatic disease setting can assist clinicians in genetic counseling. Tumour MMR testing has strong predictive value for the use of immune ...