DNA mismatch repair-deficient and -proficient cells showed similar subcellular distributions of meta-tetra(hydroxyphenyl)chlorin as analysed by laser scanning and fluorescence microscopy. Therefore, repeated exposure of tumour cells to photodynamic therapy does not seem to result in loss of DNA mismatch ...
four key genes: mutL homologue 1 (MLH1), postmeiotic segregation increased 2 (PMS2),mutS homologue 2(MSH2), and mutS 6 (MSH6). If one or more proteins are not expressed or are dysfunctional, the status is called dMMR; otherwise, the status is considered mismatch repair proficient (pMMR...
This correlates with the fact that MSH3 mutations are very rare in human HNPCC, and to the fact that the MSH2–MSH6 complex is partially redundant for repair of a single base insertion. MSH6−/− mice have reduced survival (50% survival at 11 months) with a tumour spectrum similar to...
Mismatch repair status and clinicopathological characteristics The relationship between MMR status and clinicopathological characteristics is displayed in Table 2. Patients with dMMR CRC were more likely to have a colonic primary and poor tumour differentiation (both P<0.05). In addition, although not as...
Tumor budding and a proficient mismatch repair (pMMR) status are considered adverse prognostic factors in colorectal cancer (CRC). The aim of this pilot study was to assess tumor budding in primary CRC with pMMR versus that with deficient mismatch repair (dMMR). Tumor budding was retrospectively...
these observations suggest that firstly, high-grade adenomas, irrespective of size or site, represent the most likely lesions in which to screen for Lynch syndrome, and second, that a high-grade lesion that is mismatch repair proficient decreases the likelihood that Lynch syndrome will be diag- ...
A scoping review and meta-analysis on the prevalence of pan-tumour biomarkers (dMMR, MSI, high TMB) in different solid tumours Article Open access 28 November 2022 Introduction Mismatch repair deficiency (MMRd) occurs in ~10–15% of colorectal carcinomas (CRC) and ~25–30% endometrial carc...
MLH1, MutL homolog 1; MSH2, MutS protein homolog 2; MSH6, MutS homolog 6; MSI-H, microsatellite instability high; MSI-L, microsatellite instability low; MSI-S/MSS, microsatellite stable; NCI, National Cancer Institute; pMMR, proficient mismatch repair; PMS2, postmeiotic segregation increased 2...
Of these, one patient was later found to have a microsatellite-stable and mismatch repair-proficient tumour with a low tumour mutation burden and was thus excluded from activity analyses (figure 1). Of the remaining 52 patients, 51 (98%) had a mismatch Discussion In this phase 2 trial, a...
Recommendation: Tumour mismatch repair (MMR) testing Immunohistochemistry (IHC) tests for MMR proteins or PCR tests for microsatellite instability (MSI) in the metastatic disease setting can assist clinicians in genetic counseling. Tumour MMR testing has strong predictive value for the use of immune ...