miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.Alvarez-Saavedra M, Antoun G, Yanagiya A, Oliva-Hernandez R, Cornejo-Palma D, Perez-Iratxeta C, Sonenberg N, Cheng HY
The pro-atherosclerotic effect of AT-EX is associated with the MiR-132/212-GNA12/PTEN signaling in vitro.ANormalized atherosclerosis-related miRNA levels in SAT-EX and VAT-EX.BThe potential target genes of the miR-132/212 cluster were predicted by bioinformatic analysis.CG protein subunit alpha...
调节血管生长的开关miRNA-132 科研人员发现了一种可调节血管生长的“开关”——微型核糖核酸分子miR-132,并且找到了控制该“开关”的方法。这一研究成果有望对癌症和心脑血管疾病的治疗产生积极影响。这项研究由美国加州大学圣迭戈分校医学院和密歇根大学癌症中心的研究人员共同完成。研究小组在英国《自然·医学》杂志网络...
在本研究表明,在联合治疗中,超声波强度越大,miRNA⁃132和miRNA⁃34a表达水平越低,神经病理性疼痛发生发展的活跃性会受到抑制,这或许与联合治疗可最大限度刺激miRNA⁃132和miRNA⁃34a表达水平的降低有关。其可能的机制是下调miRNA⁃...
www.nature.com/cddiscovery ARTICLE OPEN MiRNA-132/212 regulates tight junction stabilization in blood–brain barrier after stroke Haomin Yan 1, Hideaki Kanki1, Shigenobu Matsumura2, Tomohiro Kawano1, Kumiko Nishiyama1, Shintaro Sugiyama1, Hiroshi Takemori3, Hideki Mochizuki1 and Tsutomu Sasaki 1 ...
Pathological growth of cardiomyocytes (hypertrophy) is a major determinant for the development of heart failure, one of the leading medical causes of mortality worldwide. Here we show that the microRNA (miRNA)-212/132 family regulates cardiac hypertrophy
探究miRNA-132（miR-132）通过Hedgehog 信号通路对肝细胞癌细胞凋亡的机制。方法：用miR-132类似物转染人肝癌HepG2细胞，将样本分为空白组（无转染HepG2）、NC 组（HepG2转染miR-132-NC ）、YJ 组（HepG2转染miR-132 mimic ）。通过qRT-PCR 检测miR-132在HepG2细胞中的表达量，采用CCK-8法、流 式细胞...
miRNA-132/212 Deficiency Disrupts Selective Corticosterone Modulation of Dorsal vs. Ventral Hippocampal Metaplasticity. Int. J. Mol. Sci. 2023, 24, 9565. https://doi.org/10.3390/ ijms24119565 Academic Editor: Giuseppina Martella Received: 8 May 2023 Revised: 21 May 2023 Accepted: 25 May 2023 ...
We also examined the expression of miR-132 in the CA1 subfield, which is not significantly damaged in the injury model. In contrast to findings for CA3, miR-132 was not up-regulated in the CA1 subfield after status epilepticus alone (Figure 5B). Ago-2 both contributes to miRNA-mRNA ...
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