本文介绍的技术miRNA7™包括miR-21, miR-26a, miR-27a, miR-122, miR-192, miR-223, miR-801,该技术较现有血清肿瘤标志物(如AFP)具有更好的灵敏度和特异度,在AFP阴性肝癌患者中仍具有较高的肝癌患者检出率。结合现有临床检测手段, miRNA7™能...
miRNA-7全文 下载积分: 50 内容提示: FEBS Letters 587 (2013) 2247–2253journal homepage: www. FEBSLetters. orgMicroRNA-7 downregulates XIAP expression to suppress cell growth andpromote apoptosis in cervical cancer cellsShang Liu1 , Peipei Zhang 1 , Zheng Chen 1 , Min Liu, Xin Li, Hua ...
3.3. HBx Upregulated miRNA-7 (miR-7) Expression to Reduce EGFR Protein Level in HCC Cells. The mechanism underlying the regulation of EGFR 3?? UTR activity by HBx was further explored. It is well documented that miR-7 plays critical roles in the downregulation of EGFR expression in many ...
miRNA-7全文 1521-0111/83/4/857–869$25.00 /10.1124/mol.112.082743 MOLECULAR PHARMACOLOGY Mol Pharmacol 83:857–869, April 2013 Copyright ª 2013 by The American Society for Pharmacology and Experimental Therapeutics Lapatinib-Mediated Cyclooxygenase-2 Expression via Epidermal Growth Factor Receptor/HuR...
川内首家肝癌mirna7基因检测项目全面上线 为了能给肝癌患者提供先进的医疗服务,提升肝癌标准化治疗水平,推动肝癌精准医疗发展。绵阳四0四医院(绵阳市第一人民医院)病理科现已全面开展肝癌miRNA7™基因检测项目成为了川内首家开展肝癌项目的医疗机构。 肝癌在我国恶性肿瘤发病率中排名第四,死亡率排名第二,并呈持续增长...
《基于miRNA-7和Wnt信号通路的18β-甘草次酸胃癌化学预防机制研究》是依托吉林大学，由曹雪源担任项目负责人的面上项目。项目摘要 药食两用植物甘草中提取的18β-甘草次酸(GRA)具有高效抗肿瘤活性。本项目组前期工作发现GRA能够抑制胃癌细胞增殖和诱导细胞凋亡;同时探索了GRA抑制幽门螺杆菌感染胃粘...
成熟miRNA在体液中非常稳定,并且在不同癌症状态下具有极高的特异性,这使得miRNA可以作为人类癌症的潜在非侵入性的肿瘤标志物。 miRNA与肝癌 已有报道,肝癌患者具有特异的血浆microRNA表达谱。 复旦大学附属中山医院利用高通量芯片在934份血浆样本(对照组包括健康人,慢性乙肝患者,肝硬化患者)中筛选并验证到由7个microRNA...
7真核表达载体并观察其对人肺癌细胞体外生长的影响 方法 以人肺癌细胞系9 5 D细胞基 因组D NA为 模板sP C R法扩 增m i R 7前 体 序列s 经B a m I和H i nd皿双酶 切后 将其 亚克 隆入 真核表达载体 p c D NA 3 1 s 并进行酶切及测序鉴定3 将构建成功的p c D NA 3 1 p r i m...
between PAX6 and miR-7 appears to be highly conserved; however, the precise number o sites through which this interaction occurs may have expanded throughout evolution. Key words: miR-7, PAX6, miRNA, 3′-U R CitAtion: needh e e . reg H PaX6 Exp e b r-7. Evolutionary Bioinformatics...