17.Park, W., Li, J., Song, R., Messing, J. & Chen, X. CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana. Curr. Biol 12, 1484–1495 (2002). 18.Chen, X. microRNA biogenesis and function in plants. FEBS Letters 579,...
(2016). miRNA Biogenesis: A Dynamic Pathway. Trends in plant science 21:1034-1044.6. Telfer, A., and Poethig, R.S. (1998). HASTY: a gene that regulates the timing of shoot maturation in Arabidopsis thaliana. Development 125:1889-1898.7. Bollman, K.M., Aukerman, M.J., Park, M...
miRNA biogenesis: a dynamic pathway. Trends Plant Sci 2016;21(12):1034-44.Achkar, N. P., Cambiagno, D. A., and Manavella, P. A. (2016). miRNA biogenesis: a dynamic pathway. Trends Plant Sci. 21, 1034-1044. doi: 10.1016/j.tplants.2016. 09.003...
miRNA的产生过程(biogenesis) (miRNA作用示意图)MicroRNA简称miRNA,是一类单链结构的小分子RNA,一般长18-25nt。大家注意,它的长度我们用的单位是nt而非bp,正是因为它是单链的结构。而它这样的单链结构,可以和靶基因3’-UTR(3’-Untranslated Region)互补配对,实现对靶mRNA的降解(perfect complementarity)或抑制翻译...
参考文献1. Hongyu Liu, et al. Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 2018 Feb 22; 17(1): 64.2. Dónal O'Carroll, et al. General principals of miRNA biogenesis and regulation in the brain. Neuropsychopharmacology. 2013 Jan; 38(1): ...
Circular RNAs:from biogenesis and function to diseases[J].Chin Med J (Engl),2019,132(20):2457-2464.DOI:10.1097/CM9.0000000000000465. SolomonMC, RadhakrishnanRA.MicroRNA’s-the vibrant performers in the oral cancer scenario[J].Jpn Dent Sci Rev,2020,56(1):85-89.DOI:10.1016/j.jdsr.2020.04...
2. Dónal O'Carroll, et al. General principals of miRNA biogenesis and regulation in the brain. Neuropsychopharmacology. 2013 Jan; 38(1): 39-54. 3. Jessica Sheu-Gruttadauria, et al. Structural Basis for Target-Directed MicroRNA Degradation. Mol Cell. 2019 Sep 19; 75(6): 1243-1255....
胚胎植入是妊娠过程的起始阶段,囊胚必须黏附并入侵接受性母体子宫内膜,以获得氧气和营养的供应;但胎儿是一种半同种异体移植物,一旦进入子宫必然会遭到母体的免疫排斥,因此建立并维持母-胎免疫耐受对植入成功至关重要。微小RNAs(microRNAs,miRNAs)是一类内源...
then，prethenucleustothecytoplasm．Onceinthecytoplasm，pre-miRNAsalerecognizedcytoplasm．cytoplasm，preandprocessedintotheirmatureformbyanotherRNaseIII，Dicer．TheprocedureRNaseIII，Dicer．isbrieflysummarized,andthebiogenesisofplantmiRNAsisalsodiscussed．discussed．FurtherresearchonthepathwayofmiRNAmaturationcanhelpusto...
pre-miRNAs)soonbyanRNaseIIIfamilynuclease,Drosha；then，pre-miRNAsaretransportedfromthenucleustothecytoplasm．Onceinthecytoplasm，pre-miRNAsalerecognizedandprocessedintotheirmatureformbyanotherRNaseIII，Dicer．Theprocedureisbrieflysummarized,andthebiogenesisofplantmiRNAsisalsodiscussed．Furtherresearchonthepathwayof...