[8] Kim VN: MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005, 6:376-385.[9] Ibanez-Ventoso C, Vora M, Driscoll M: Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS...
[9] Ibanez-Ventoso C, Vora M, Driscoll M: Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS One 2008, 3:e2818. [10] Fabian MR, Sonenberg N: The mechanics of miRNA-mediated gene silencing: a look...
[9] Ibanez-Ventoso C, Vora M, Driscoll M: Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS One 2008, 3:e2818. [10] Fabian MR, Sonenberg N: The mechanics of miRNA-mediated gene silencing: a look...
Mutational analysis of the miR-10a sequence revealed that the 3' end of the miRNA sequence is the most critical element for the silencing effect. MicroRNA-10a-induced transcriptional gene inhibition requires the presence of Dicer and Argonautes 1 and 3, and it is related to promoter associated ...
[9] Ibanez-Ventoso C, Vora M, Driscoll M: Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS One 2008, 3:e2818. [10] Fabian MR, Sonenberg N: The mechanics of miRNA-mediated gene silencing: a look...
[9] Ibanez-Ventoso C, Vora M, Driscoll M: Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS One 2008, 3:e2818. [10] Fabian MR, Sonenberg N: The mechanics of miRNA-mediated gene silencing: a look...
[9] Ibanez-Ventoso C, Vora M, Driscoll M: Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS One 2008, 3:e2818. [10] Fabian MR, Sonenberg N: The mechanics of miRNA-mediated gene silencing: a look...
如 miR-10a 通过与核 糖体蛋白 mRNA 的 5'UTRs 相互作用来增强 mRNA 的翻译[41];miR-346 除了与 3'UTR 结合激活翻译之 外[42],还可以通过靶向 RIP140 mRNA 的 5'UTR 来 提高 RIP140 蛋白水平[43];miR-483-5p 也被证明可 以通过与 IGF2 mRNA 的 5'UTR 结合来促进 IGF2 转录[44].此外,在...
Down-regulation of CXCR4, that is, the SDF-1 receptor, on the other hand, caused up-regulation of miR10a, miR151, miR425, and miR5100 in myoblasts. Interestingly, microarray analysis showed that three of these miRNAs, i.e., miR10a, miR425, and miR5100, regulated the level of ...
miRISC由miRNA引导,识别一段位于靶点mRNA3’UTR区域、与miRNA互补的特异序列,与该靶点mRNA结合,造成mRNA降解,或抑制mRNA翻译,这段互补序列也被称作miRNA的种子序列(seed sequence)。从目前已有的实验及计算机预测结果来看,一个miRNA可能抑制超过100种mRNA,人体中有超过60%的蛋白编码基因的mRNA 3’UTR区域包含有miRNA...