近日，上海交通大学医学院附属第九人民医院的郭海艳、张建军在Cellular and Molecular Life Sciences上发表了题为“Nuclear miR 451a activates KDM7A and leads to cetuximab resistance in head and neck squamous cell carcinoma” 的研究论文。该研究发现，miR-451a在西妥昔单抗耐药细胞核中富集，并通过由AGO2介导...
miR-451a 的表达模式:研究发现,miR-451a 在 HCV 和 HBV 感染患者的肝脏组织中表达下调,且随着疾病从慢性肝炎向肝硬化、肝细胞癌进展,其表达量显著降低。在 Huh7 和 SNU449 细胞系中,病毒感染同样导致 miR-451a 表达下调,这表明 miR-451a 在慢性肝炎的发展过程中可能发挥着重要的保护作用。 miR-451a 的靶...
细胞衰老通常与氧化压力增加相关,研究发现往正常细胞加入miR-10a、-30c以及-451a干预后,细胞环境内活性氧的数量相比空白对照组增加(绿色染色)。反之,向衰老成纤维细胞加入miR-10a、-30c以及-451a的抑制剂干预后,细胞环境内活性氧的数量相比空白对照组减少。 研究还发现,miR-10a、-30c以及-451a会阻碍线粒体自噬...
本发明公开了一种miR‑451a反义链抑制剂及其应用。本发明通过建立小鼠酒精性肝病模型,对模型组和正常对照组小鼠肝组织进行小分子RNA深度测序,分析筛选得到差异高表达的miR‑451a,并利用qRT‑PCR进行验证。化学合成miR‑451a反义链抑制剂,进行小鼠体内实验,结果表明miR‑451a反义链抑制剂有效地降低酒精性脂肪...
摘要 目的探讨miR-451a对人绒毛外滋养细胞侵袭能力的调节机制。方法以人工合成的寡核苷酸miR-451a模拟物(miR-451a mimics)转染人绒毛外滋养细胞株HTR-8/SV neo细胞,应用逆转录-实时PCR法检...展开更多 Objective To investigate the regulatory mechanism of miR-451a on the invasion of human villous trophoblast...
结论:本研究发现血浆miR-451a在SLE病人中表达升高,提示miR-451a可能与SLE的发病有关.此外,miR-144-3p表达在伴有蛋白尿SLE的病人中高于不伴有蛋白尿的病人,miR-144-3p血浆表达水平可能与SLE病人的尿蛋白水平有关. 展开 关键词:microRNAs 血浆红斑狼疮 系统性 分子流行病学 ...
miR-451a and miR-486-5p in bone marrow and peripheral blood after benzene exposure, along with their correlations with erythrocyte indices. In C57BL/6J mice exposed to benzene, the expression levels of miR-451a and miR-486-5p in bone marrow decreased, which also positively correlated with ...
Functionally, miR-451a represses the malignant progression of osteosarcoma. Mechanically, miR-451a could curb the AKT/mTOR pathway via 3-phosphoinositide dependent protein kinase 1 (PDPK1)-mediated phosphorylation modification. After the certification that YTH domain containing 1 (YTHDC1) regulates the...
These findings emphasized the important role of miR-451a and miR-486-5p in benzene-induced erythrogenesis disruption, offering valuable insights for biomarker development and therapeutic interventions. 展开 关键词: Benzene miR-451a miR-486-5p Erythroid damage ...
Cellular and Molecular Life Sciences (2024) 81:282 https://doi.org/10.1007/s00018-024-05324-x ORIGINAL ARTICLE Cellular and Molecular Life Sciences Nuclear miR‑451a activates KDM7A and leads to cetuximab resistance in head and neck squamous cell carcinoma Peisong Zhai1 · Tong...