当MIR210HG在Ishikawa和HEC-1A细胞中过表达时,miR-337-3p和miR-137表达水平降低。相比之下,转染sh-MIR210HG后,细胞中miR-337-3p和miR-137的表达水平显著升高,说明MIR210HG可以调控miR-337-3p和miR-137的表达(图4F)。随后,我们研究了miR-337-3p和miR-137是否负调控MIR210HG的表达,发现过表达miR-337-3p/137...
从机制上讲,MIR210HG 通过直接结合 HIF-1α mRNA 的 5'-UTR 来增强代谢转录因子缺氧诱导因子 1α (HIF-1α) 的翻译,导致 HIF-1a 蛋白水平升高,从而上调糖酵解酶的表达。TNBC 细胞中 MIR210HG 的敲低降低了它们的糖酵解代谢并消除了它们的致瘤潜力,表明 MIR210HG 在 TNBC 中具有糖酵解依赖性致癌活性...
Conclusions:In breast cancer, MIR210HG functions as an oncogenic lncRNA, which is also mediated by its encoded miR-210. In addition, both IGF2BP1 and ELAVL1 enhance the stability of MIR210HG, which contributes to the progression of breast cancer. Interestingly, IGF2BP1 is directly activated ...
摘要: LncRNA-MIR210HG plays crucial roles in the progression of diverse cancers. However, the expression and function of MIR210HG in ovarian cancer remains unclear. In the present study, we aimed to determine the expression and function of lncRNA-MIR210HG in ovarian cancer under hypoxic condit...
铁死亡是一种铁依赖性程序性细胞死亡模式,被证明能够调控多种血管疾病的疾病进程.长链非编码RNA是人类基因组中重要调节因子,可在表观遗传,转录抑制,转录后调节和核内运输等多种途径调控疾病的病理生理过程.本研究的目的是探讨LncRNA MIR210HG调节低氧性肺动脉高压分子机制,以及其是否通过自噬依赖性铁死亡通路调节PASMCs...
miR210HG,SH3BGRL3表达水平高于癌旁组织(P<0.05).lncRNA-miR210HG阳性表达者Ⅲ期占比,淋巴结转移占比高于阴性表达者;SH3BGRL3阳性表达者Ⅲ期占比,淋巴结转移占比,低中分化占比高于阴性表达者(P<0.05).lncRNA-miR210HG,SH3BGRL3阳性组总生存率均低于阴性组(P<0.05).结论lncRNA-miR210HG,SH3BGRL3在...
MIR210HG may have the capacity to augment the vitality and invasion of CRC cells and suppress cell apoptosis, and this influence is counteracted by miR-1226-3p. Conclusion: lncRNA MIR210HG accelerated the progression of colorectal cancer by controlling miR-1226-3p. lncRNA M...
RT-PCR quantitative was utilized to determine the expression level of LncRNA MIR210HG in PASMCs. LPO, ROS and GSH/GSSG kits were used to evaluate the ferroptosis levels in PAMSCs. The indirect regulatory relationship between STAT3, HIF-2α and MIR210HG was detected by transfection of STAT3,...
MIR210HGmiR-93-5pChronic hypoxia in the renal tubular interstitium has been reported to contribute to the progression of chronic kidney disease. Recently, long-noncoding RNAs have been shown to be involved in various pathological conditions, including hypoxia, one of which is the MIR210 host ...
LncRNA MIR210HG is a long non-coding RNA closely related to hypoxia and has been widely reported in a variety of tumor diseases. But its mechanism in hypoxic pulmonary hypertension is not clear. In this study, we identified for the first time the potential effect of MIR210HG on disease ...