MCE 国际站:mmu-miR-128-1-5p mimic 产品活性:mmu-miR-128-1-5p mimic 是一种化学合成的miRNA模拟物,能模拟内源性miRNA,上调miRNA活性,用于功能获得性(gain-of-function)研究。 研究领域:Epigenetics 作用靶点:MicroRNA 相关产品:hsa-miR-4728-3p agomir | hsa-miR-126-3p agomir | rno-miR-6323 antagomi...
专利摘要:本发明属于生物医学领域,具体涉及miR‑128‑1‑5p在制备治疗I型超敏反应的药物中的应用。所述miR‑128‑1‑5p的序列如SEQIDNO.1所示。体内、体外实验表明,所述miR‑128‑1‑5p可靶向EGR3抑制细胞脱颗粒,通过调控AKT与ERK信号通路,起到抑制I型超敏反应的作用。 专利权项:1.miR-128-1-...
中文名称:hsa-mir-128-1-5p RT-PCR反应引物 英文名称:hsa-mir-128-1-5p RT-PCR Primer Set 品牌:Abbexa 货号:abx096853 规格:1 nmol 价格: $246.5 产品说明书下载: 产品预定 >> 产品预定,提交订单信息之后,我们会第一时间与您取得联系 试剂和工具 ...
摘要: We first verified ADSC-Exosomal miR-128-1-5p can inhibit skin fibrosis.Our data revealed ADSC-Exos can inhibit TGF-β1 expression induced by high glucose.ADSC-Exos can decrease α-SMA and Col I through the miR-128-1-5p/TGF-β1/Smad axis.关键词:...
本研究拟在此基础上进一步证实Rap1B是miR-128、miR-149及miR-181的直接调控靶基因,并证实它们在不同WHO分化级别的星形胶质细胞瘤中的表达变化,进而阐明miR-128、miR-149及miR-181通过靶向Rap1B对脑胶质瘤细胞增殖和侵袭的影响以及增强替莫唑胺(temozolomide, TMZ)对脑胶质瘤细胞化疗敏感性的作用机制。 [Rap1B...
实验结果显示,在类风湿关节炎患者中NEAT1表达水平升高,而miR-128-3p和SIRT1表达水平降低。此外,研究还发现LncRNA NEAT1可以通过吸附miR-128-3p来抑制miR-128-3p的表达,从而增强SIRT1的表达,促进自噬进程。 4. 结论 本研究表明,LncRNA NEAT1/miR-128-3p/SIRT1通路在类风湿关节炎自噬调控过程中具有重要的作用。
Moreover, inhibition of miR-128 reversed the inductive effect of PCAT-1 knockdown on DDP sensitivity of GC cells. In addition, ZEB1 was identified as a target of miR-128, and overexpression of ZEB1 could block the inductive effect of PCAT-1 knockdown on DDP sensitivity of GC cells. ...
Materials and methods: The expression levels of SNHG16, miR-182-5p, miR-128-3p and LASP1 in retinoblastoma tissues and cell lines were detected using qRT-PCR. The migratory and invasive abilities of retinoblastoma cells were assessed using Transwell assay. The regulatory relationships among SNHG...
Here, we found that miR-128 expression was elevated in the acute seizure phase and decreased during the recurrent seizure phase after status epilepticus in mice. Both SNAP-25 and SYT1 are regulated by miR-128 in vitro and in vivo. Overexpressing miR-128 in cultured neurons decreased ...
All in all, OIP5-AS1 overexpression enhanced sepsis-induced ALI by modulating the miR-128-3p/SIRT1 pathway, which helps create new insights into sepsis treatment. 展开 关键词: Sepsis lung injury OIP5-AS1 miR-128-3p SIRT1 DOI: 10.1080/21655979.2021.1987132 ...