miR-515-5p抑制剂组、miR-515-5p抑制剂阴性对照(negative control, NC)组,CCK-8法检测细胞增殖情况;划痕愈合和Transwell实验分别评估细胞迁移、侵袭能力;双荧光素酶报告基因检测miR-515-5p和ITLN2的靶向关系;RT-qPCR技术检测各组细胞...
miR-515-5p 通过靶向TPX2-IL-6 轴抑制食管癌细胞增殖,迁移和侵袭doi:10.3969/j.issn.1000-484X.2024.12.017袁志高税明才周辉Chinese Journal of Immunology
MiR-515-5p acts as a tumor suppressor via targeting TRIP13 inprostate cancerXiyan Zhanga , Jian Zhou b , Dongwei Xue c , Zhi Li d , Yili Liu c , Liming Dong c, ⁎aDepartment of General Surgery, The Fourth Aff i liated Hospital of China Medical University, Liaoning 110000, Shenyang...
结果EMT患者在位和异位子宫内膜组织miR-515-5p相对表达量显著高于正常子宫内膜组织(均 P<0.001), ITLN2 mRNA相对表达量显著低于正常子宫内膜组织,异位子宫内膜组织 ITLN2 mRNA相对表达量显著低于在位子宫内膜组织(均 P<0.001),EMT患者异位子宫内膜组织ITLN2蛋白质水平显著低于EMT在位和正常子宫内膜组织(均 P<0.001)...
货号:ppy-miR-515-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:ppy-miR-515-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
Journal of Experimental & Clinical Cancer Research https://doi.org/10.1186/s13046-019-1421-7 (2019) 38:418 RESEARCH Open Access LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway Kun Qiao1, Shipeng Ning1, ...
Mechanistically, LINC00673 was found to act as a ceRNA by sponging miR-515-5p to regulate MARK4 expression, thus inhibiting the Hippo signaling pathway. Finally, ChIP assay showed that the transcription factor Yin Yang 1 (YY1) could bind to the LINC00673 promoter and increase its transcription...
本研究旨在探究贝伐珠单抗辅助PD-1抑制剂治疗胃癌对血清miR-20a-5p和miR-515-3p的影响。 [摘要] 背景与目的:二联合用药对胃癌的治疗效果不佳,贝伐单抗为抗血管新生的靶向抗肿瘤药,信迪利单抗为国内自主研发的PD-1抑制剂,二者联合应用有望成为胃癌治疗的新方向。
探讨血清miR-199b-5p,外周血中性粒细胞/淋巴细胞比值(NLR),血小板/淋巴细胞比值(PLR),全身免疫炎症指数(SII)在急性冠状动脉综合征(ACS)中的表达,并分析其临床应用价值.方法:选取东部战区总医院2020年3月至2020年12月收治的ACS患者62例及同期东部战区总医院体检中心健康对照者56例作为研究对象.比较两组的一般资料,...
(DEGs) regulated by miR-34a-5p that are associated with adipogenesis.The GSE26764 transcription profile was downloaded from the Gene Expression Omnibus database,and includes data from three samples of negative control transfected C2C12 cells,three samples of miR-34a-5p transfected C2C12 cells.The ...