miR-509–5p upregulation inhibited Caco-2 cell viability. SLC7A11 was predicted to be the cellular target of miR-509–5p. Interestingly, miR-509–5p's overexpression suppressed both mRNA and protein levels of SLC7A11, whereas its downregulation boosted SLC7A11 gene expression. Finally, ...
The miR-509-5p/miR-124 ratio of liquid biopsies in diagnosis of bladder cancer 在线阅读 免费下载 引用 收藏 分享 摘要 背景与目的:液态活检是一种从血液、尿液等非实体生物组织中取样分析,主要用于恶性肿瘤诊断、监测及判断预后的方法。该研究通过优化尿液mi RNA的提取方法,建立标准化的液态活检手段,筛选并...
miR-509-5p mimic markedly inhibited PANC-1 cell proliferation, migration, and invasion. Conversely, miR-509-5p inhibitor promoted PANC-1 cell proliferation, migration, and invasion. Furthermore, the 3'UTR-specific target site luciferase reporter assay also showed that miR-509-5p negatively ...
Building Ai-634, Xinzao Town, Panyu District, Guangzhou 511436, People's Republic of China Tel +86 20 3710 3286 Fax +86 20 3710 3286 Email chenfc84@163.com Objective: This study aimed to explore the effect of miR-509-5p on pancreatic cancer progression and clarify the underlying mechanism...
Although the Mdm2/p53 interaction has been well documented, it is not clear whether there are new microRNAs participating in this regulatory network. Here, we provide evidence that miR-509-5p, which is downregulated in a subset of newly diagnosed cervica
Although the Mdm2/p53 interaction has been well documented, it is not clear whether there are new microRNAs participating in this regulatory network. Here, we provide evidence that miR-509-5p, which is downregulated in a subset of newly diagnosed cervica
Restoration of Mdm2 abrogated the cell phenotypes induced by miR-509-5p. Moreover, ectopic expression of miR-509-5p in HeLa and QGY-7703 cells repressed the expression of Mdm2, subsequently enhancing its p53-activating effects. These results suggest that miR-509-5p is a new regulator of Mdm2...
miR-509-5p/miR-124 ratio in the urine was found higher in patients with bladder cancer than in healthy controls (<0.000 1). With the rise of miR-509-5p/miR-124 ratio in urine, tumor stage and grade were also increased (=0.003). When the cutoff was set at 0.41, the diagnostic ...
hsa-miR-509-3-5p inhibitor CAS No. : MCE 国际站:hsa-miR-509-3-5p inhibitor 产品活性:hsa-miR-509-3-5p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制miRNA的功能,可用于miRNA 功能缺失性(loss-of-function...