研究人员首次发现 miR-340-5p 在 ENKTL 肿瘤细胞中,尤其是在依托泊苷耐药的 ENKTL 细胞中,对 PD-L1 表达起着重要的调控作用。血清 miR-340-5p 水平与 PD-L1 表达、可溶性 PD-L1 水平以及帕博利珠单抗的治疗反应均密切相关,这意味着在治疗前检测血清 miR-340-5p 水平,或许能够帮助医生更好地选择适合的治疗方...
在靶mRNA中,miR-340-5p显著降低了LBR mRNA的表达水平,编码LBR(lamin B receptor,LBR)。通过异位过表达miR-340-5P在叶片相关区域去抑制异染色质,促进具有衰老特征的DNA重复元件的表达,从而导致LBR的丢失。重要的是,过表达miR-340-5p增...
近日,发表在Nucleic Acids Research杂志上题为“Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis”证明了miR-340-5p是一种促进细胞衰老的新型miRNA,而miR-340-5p促进...
MicroRNA-340-5p (miR-340-5p), a suppressor of certain target genes in brain, reportedly is decreased in peripheral circulation of acute stroke patients. However, little is known regarding its role in regulating cerebral ischemia/reperfusion injury. This study explores the effect of miR-340-5p ...
Subsequently, mechanism studies showed that LINC01354 positively regulated the ATF1 expression via competitive binding to miR-340-5p. Therefore, our results illustrated that LINC01354 might act as an oncogenic role by modulating the miR-340-5p/ATF1 axis, providing a novel therapeutic therapy for ...
血清外来体mir-340-5p促进氧-糖剥夺期间脑微血管内皮细胞血管生成 相关领域 血管生成 微泡 体内 外体 内皮干细胞 医学 癌症研究 体外 小RNA 生物 生物化学 基因 生物技术 网址 https://doi.org/10.1007/s11064-021-03492-x DOI 10.1007/s11064-021-03492-x 复制 doi ...
中文摘要: 目的 探讨阿司匹林(Asp)通过调节微RNA-340-5p(miR-340-5p)/高迁移率族蛋白1(HMGB1)/Toll样受体4(TLR4)通路对大鼠心肌缺血/再灌注(I/R)损伤的影响。方法将雄性SD大鼠分为假手术(Sham)组(开胸不结扎)、I/R组(构建I/R损伤模型)、Asp预处理(I/R+Asp)组(Asp预处理7d+造模)、I/R+Asp+in-miR...
货号:cgr-miR-340-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:cgr-miR-340-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
Validation in larger cohorts is necessary to confirm the utility of miR-340-5p as a predictive biomarker for ENKTL immunotherapy. 展开 关键词: PD-L1 miR-340-5p NK/T-cell Lymphoma Biomarkers DOI: 10.1038/s41598-025-90542-x 年份: 2025 ...
These results provided evidences that miR-340-5p regulated MFF-SIRT1/3 axis to improve mitochondrial homeostasis and proliferation–apoptosis imbalance of hypoxia-treated PAMSCs, which provided a theoretical basis for the prevention and treatment of PAH....