进一步的研究表明,miR-320a-3p通过抑制FOXQ1的表达,影响卵巢颗粒细胞的增殖和凋亡,从而延缓卵巢衰老。此外,研究团队还发现hnRNPA2B1参与调控miR-320a-3p进入外泌体,这一发现为理解外泌体在卵巢衰老中的作用提供了新的视角。 李晶课题组、相文佩课题组和张玲课题组的这项研究的发现不仅揭示了卵泡液外泌体在卵巢衰老...
The present study found that, compared with lung tissue of healthy control subjects, the expression of miR-320a-3p in lung tissue of PF patients was significantly reduced. The expression levels of miR-320a-3p decreased in TGF-尾1-stimulated A549 cells in a time- and concen...
The hsa-miR-320a-3p and hsa-miR-483-5p levels were not associated with clinical pregnancy. However, multiple regression analysis indicated that in Q3 and Q4 intervals had experienced a decreased chance of live birth due to high expression levels of hsa-miR-320a-3p and hsa-miR-483-5p ...
本发明公开了miR320a3p作为内参基因在法医体液鉴定中的应用.miR320a3p的核苷酸序列如SEQ ID NO:3所示.实验证明,miR320a3p是外周血,月经血,唾液,精液和阴道分泌液中表达最稳定的内参基因,其与RNU6b的组合增强了归一化效力.本发明通过确定合适的内参基因以进行严格的归一化,可以促进基于miRNA的体液鉴定的发展和应用...
MiR-320a and miR-483 levels were found to be associated with PK and PD profiles of rivaroxaban in healthy Chinese subjects. Further studies are required to verify these findings and explore the mechanisms.doi:10.1186/s40246-022-00445-5Zhang, Hanxu...
Integrin [beta]1 (ITG [beta]1) was found to be one of the targets of miR-320a-3p. An enzyme-linked immune sorbent assay demonstrated that the ITG [beta]1 concentration increased significantly in the patients' serum, and the in vitro study confirmed that miR-320a-3p targeted the 3' ...
While other miRNAs such as hsa-miR-320a-3p, hsa-miR-186-5p, and hsa-miR-486-5p, showed a significant re-upregulated after day 21.#In summary, the PBCs at days 14 and 21 had the lowest levels of miRNAs, which may indicate less of a relationship with storage lesions. However, older...
本发明属于生物医药技术领域,具体公开了FKBP5及hasmiR320a3p在HIV感染人群中诊断结核病的应用.本发明发现FKBP5及hasmiR320a3p可以作为诊断HIV/AIDS人群感染结核病的生物标志物,且具有敏感性高,特异性高,检测速度快等优点,适用于HIV/AIDS人群中结核病的筛查;本发明为HIV合并结核分枝杆菌感染的诊断提供了一种新的生物...
miR-320a-3pBackground:N Methods:We performed studies with fibroblast cell lines and silica-induced mouse pulmonary fibrosis models. The expression of ALKBH5, miR-320a-3p, and forkhead box protein M1 (FOXM1) was determined by quantitative real-time polymerase chain reaction (qRT-PCR) analysis....
The relative hsa-miR-320a-3p expression levels in granulosa cells were weakly and positively correlated with the patient age ( P =0.0033). Moreover, both the basal follicle stimulating hormone ( P =0.0003) and ovarian stimulation protocols ( P =0.006 and P =0.004) significantly and positively...