LIR+miR-mimic+T2DM组中破骨细胞增多,β细胞凋亡增加,外泌体中miR-31a-5p表达增加,E2F2表达减少(P<0.05).E2F2被证实是miR-31a-5p的靶基因,与E2F2突变组(E2F2-MUT组)相比,E2F2野生组(E2F2-WT组)的报告基因在mimic处理后的荧光素酶活性显著降低(P<0.01).结论LIR通过调节BMSC外泌体miR-31a-5p/E2F2信号轴改善...
该【利拉鲁肽通过调节骨髓间充质干细胞外泌体miR-31a-5p E2F2改善2型糖尿病大鼠β细胞损伤和骨 】是由【十二贾氏】上传分享,文档一共【9】页,该文档可以免费在线阅读,需要了解更多关于【利拉鲁肽通过调节骨髓间充质干细胞外泌体miR-31a-5p E2F2改善2型糖尿病大鼠β细胞损伤和骨 】的内容,可以使用淘豆网的站...
The present study evaluated the effects of miR-31a-5p on human dermal fibroblast cells (CC-2511 cells) under hyperthermic stress.Jiang, LeiXue, WenjunWang, YibingShandong Univ Shandong Prov Hosp Dept Burns &Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie...
非编码RNA-31抑制剂,骨形成,骨吸收,药理作用建立增龄性大鼠骨质疏松模型,研究骨髓微环境中的外泌体内的miR-31a-5p调控骨形成和骨吸收的作用机制,并通过对中老年大鼠股骨注射miR-31抑制剂评价其对骨质疏松的预防作用.徐荣耀,江宏兵中华口腔医学会;重庆市口腔医学会2017全国口腔生物医学学术年会...
Furthermore, the effects of IL-25 on pro-inflammatory mediators, cell proliferation and Wnt/β-catenin pathway were finally studied.Hyperthermic treatment increased miR-31a-5p expression, enhanced IL-1β, IL-6, IL-8 and TNF-α productions, as well as decreased proliferation and induced apoptosis...
MiR-31a-5p protects myocardial cells against apoptosis by targeting Tp53doi:10.3892/MMR.2017.8357MengJie YanZhiSen TianZhiHui ZhaoPing YangSpandidos Publications
circSEC31A后能够明显抑制细胞的增殖和成骨分化相关分子RUNX2,OPN的表达水平(P<0.05),促进细胞的凋亡(P<0.05).在脂肪干细胞中转染LV-circSEC31A后能够明显促进细胞的增殖和成骨分化相关分子RUNX2,OPN的表达水平(P<0.05),抑制细胞的凋亡(P<0.05).双荧光素酶结果显示circSEC31A能够靶向结合miR-324-5p(P<0.05)....