We also identified miR-30a as an AKT-FOXO3a-regulated gene that forms a feedback loop. Together, these results demonstrate that miR-30a is an upstream regulator of the Akt pathway with a critical role in cancer etiology and chemoresistance....
2557Accesses Metrics Abstract Diabetes is an inflammatory disease. Inflammation plays an important role in islet functions. However, the exact mechanisms by which inflammation affects islet functions remain unclear. In this study, we investigated the regulatory effects of miR-30a on inflammation and isle...
by bioinformatic analyses, we find several potential binding sites of RelA, a nuclear transcription factor that is activated by TLR4, in the promoter region of miR-30a gene, suggesting a possible regulating role of TLR4
Together, our data demonstrated the role of P65-miR-30a-5p-BCL2L11 loop in CAM-DR myeloma cells. These findings give new insights into the role of tumor microenvironment in the treatment of patients with myeloma.doi:10.1016/j.yexcr.2022.113113Lingling Xie...
In conclusion, there is a "miR-30a-5p-WWP1-NF-κB" positive feedback loop, which plays an important role in regulating glioma development and might provide a potential therapeutic strategy for treating glioma. Copyright 2019. Published by Elsevier Ltd....
In conclusion, there is a "miR-30a-5p-WWP1-NF-kappa B" positive feedback loop, which plays an important role in regulating glioma development and might provide a potential therapeutic strategy for treating glioma.Zhao, PeichaoWang, MengMengAn, JiyangSun, HongweiLi, TianhaoLi, Dongming...
For miRNA quantitation, stem-loop primers designed to have a short single-stranded part that is complementary to the 3′- end of miRNA, a double-stranded part (the stem) and the loop that contains the universal primer-binding sequence were used as reverse primers. For mRNA determination...