We also identified miR-30a as an AKT-FOXO3a-regulated gene that forms a feedback loop. Together, these results demonstrate that miR-30a is an upstream regulator of the Akt pathway with a critical role in cancer etiology and chemoresistance....
Furthermore, we assayed the mRNA levels of Insulin 1 and 2 (Ins1 and Ins2), pancreatic and duodenal homeobox 1 (Pdx-1), neurogenic differentiation 1(NeuroD1), cAMP responsive element modulator (Crem), basic helix-loop-helix family, and member e22 (BHLHE22) in beta-TC-6 cells by RT...
to Th17 ratio imbalance and EAE pathology [38]; however, the reasons for dysregulated expression of miR-30a in EAE mice and MS patients are unclear. Interestingly, by bioinformatic analyses, we find several potential binding sites of RelA, a nuclear transcription factor that is activated by TLR4...
In conclusion, there is a "miR-30a-5p-WWP1-NF-κB" positive feedback loop, which plays an important role in regulating glioma development and might provide a potential therapeutic strategy for treating glioma. Copyright 2019. Published by Elsevier Ltd....
In conclusion, there is a "miR-30a-5p-WWP1-NF-kappa B" positive feedback loop, which plays an important role in regulating glioma development and might provide a potential therapeutic strategy for treating glioma.Zhao, PeichaoWang, MengMengAn, JiyangSun, HongweiLi, TianhaoLi, Dongming...
Together, our data demonstrated the role of P65-miR-30a-5p-BCL2L11 loop in CAM-DR myeloma cells. These findings give new insights into the role of tumor microenvironment in the treatment of patients with myeloma.doi:10.1016/j.yexcr.2022.113113Lingling Xie...
For miRNA quantitation, stem-loop primers designed to have a short single-stranded part that is complementary to the 3′- end of miRNA, a double-stranded part (the stem) and the loop that contains the universal primer-binding sequence were used as reverse primers. For mRNA determination...