LncRNA-ATBmiR-34c-3pmiR-29b-2-5p矽肺病(Silicosis)是尘肺病的一种主要类型,是由于吸入含游离二氧化硅的粉尘引起的以肺纤维化为主的不可逆进行性疾病.矽肺病病理过程复杂,游离二氧化硅粉尘激活肺巨噬细胞,损伤肺泡上皮细胞,促进上皮间质转化,成纤维细胞激活与增殖等.这一过程包含了氧化应激,免疫应答,炎症反应及...
MiR-29b-2-5p, through repression of UNC5C expression, increases filopodia formation and Shigella capture by host cells.doi:10.1371/journal.ppat.1006327.g005S. UshasreeAguilar CarmenS. R. JorgeS. MalvikaCruz Ana RitaTawk CarolineMaudet Claire...
MiR-29b-2-5p favors Shigella binding and intracellular replication.doi:10.1371/journal.ppat.1006327.g001S. UshasreeAguilar CarmenS. R. JorgeS. MalvikaCruz Ana RitaTawk CarolineMaudet ClaireM. MiguelE. AnaPLOS Pathogens
Then, the relationship between miR-29b-2-5p and HK2 was explored by luciferase reporter gene assay. Pulmonary fibrosis cell model was induced by transforming growth factor-尾 1 (TGF-尾 1) in MRC-5 cells, and the medicated serum of DZP (DMS) was prepared in rats. MRC-5 cells were ...
MiR-29b-2-5p inhibited the nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) to control hypertrophic gene expression. After silencing circCacna1c, the expression of miR-29b-2-5p increased, which reduced hypertrophic gene expression by inhibiting ...
Mechanistically, TGF‐β1‐induced lncRNA‐ATB accelerated EMT as a sponge of miR‐29b‐2‐5p and miR‐34c‐3p and shared miRNA response elements with MEKK2 and NOTCH2, thus relieving these two molecules from miRNA‐mediated translational repression. Interestingly, the co‐transfec...
In this study, circRNA_014511 overexpression vector was constructed and transfected into bone marrow mesenchymal stem cells, miR-29b-2-5p and P53 were found to be decreased, which could be reversed by miR29b-mimics. Dual luciferase reporter assay confirmed the binding of circRNA_014511 and mmu-...
MiR-29b-2-5p is decreased upon Shigella infection.doi:10.1371/JOURNAL.PPAT.1006327.G002S. UshasreeAguilar CarmenS. R. JorgeS. MalvikaCruz Ana RitaTawk CarolineMaudet ClaireM. MiguelE. AnaPLOS Pathogens
Increase of Shigella infection induced by miR-29b-2-5p is dependent on multiple targets.Ushasree, SunkavalliCarmen, AguilarRicardo Jorge, SilvaMalvika, SharanAna Rita, CruzCaroline, TawkClaire, MaudetMiguel, ManoAna, Eulalio
miR-29b-1-5p exacerbates myocardial injury induced by sepsis in a mouse model by targeting TERF2doi:10.3724/abbs.2024020Yaqing JiangJunmei XuHua ZengZhaojing LinQiong YiJiali GuoFeng XiaoActa Biochimica et Biophysica Sinica