Conclusion miR-23b-5p relieves airway remodeling in bronchial asthma through the downregulation of FN1.白诗瑶包慧静马琳麻雪晴李丹玲苏新明Journal of China Medical University
摘要：目的探讨转化生长因子β1（TGF-β1）诱导NRK-52E （大鼠肾小管上皮细胞）细胞转分化模型中miR-23b-5p 是否能对Nrf2通路靶向调节，并阐明清肾颗粒含药血清减轻NRK-52E 细胞转分化的机制。方法构建TGF-β1诱导的NRK-52E 细胞转分化模型，分别使用miR-23b-5p mimic 、inhibitor 以及阴性对照（NC ）siRNA ...
清肾颗粒含药血清通过miR-23b-5p靶向Nrf2通路减轻NRK-52E细胞转分化 刘敏, 金华, 呼琴, 陈诺, 张叶青, 王亿平 QingshenGranules-medicated serum reduces transdifferentiation of NRK-52E cells by miR-23b-5p-mediated activation of the Nrf2 pathway
miR-23b-mimic 组,miR-23b-mimic+清肾颗粒组.采用 CCK8 法测定 NRK- 52E细胞活性;双荧光素酶报告基因实验检测miR-23b-5p与Nrf2间的靶向关系;Western blot法检测细胞中Nrf2,Keap1,α-SMA 蛋白表达;RT-qPCR 法检测细胞中 miR-23b,Keap1,Nrf2,α-SMA mRNA 表达;流式细胞术检测 ROS.结果 根据 CCK8 结果筛...
miR-155,miR-23b,miR-21-5p和PD-1的表达水平.上调miR-155,miR-23b能够通过靶向于il12B和TAB2的3'UTR区来抑制TAB2,磷酸化的IκB和IL-12 p40的水平;上调miR-21-5p能够通过靶向于il12A的3'UTR区直接抑制LPS/R848诱导的IL-12p35表达.抑制miR-... 王晓亚,黄勇,童德文 - 中国兽医病理学学术研讨会暨兽医病理...
货号:cgr-miR-23b-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:cgr-miR-23b-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
货号:chi-miR-23b-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:chi-miR-23b-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
Growing evidence demonstrates that MicroRNAs (miRNAs) play an essential role in contributing to tumor development and progression. However, the underlying role and mechanisms of miR-23b-5p in hepatocellular carcinoma (HCC) formation remain unclear. Our s
miR-23b-5p inhibited this ability of hsa_circ_0021727. MiR-23b-5p acts by targeting TAK1-binding protein 1 (TAB1). Upregulation of TAB1 can activate the nuclear factor kappa B (NFκB) pathway. Hsa_circ_0021727 promoted ESCC progression by activating TAB1/NFκB pathway by sponging miR-...
In cervical cancer (CC), miR-23b-3p, miR-124-3p, and miR-218-5p have been found to act as tumor suppressors by regulating cellular processes related to progression and metastasis. The objective of the present review is to provide an update on the experimental evidence about the role of mi...