FN1 was directly regulated by miR-23b-5p. Compared with the miR-NC group, FN1 expression levels were significantly down-regulated after transfection with miR-23b-5p mimic (P < 0.05) and significantly increased after transfection with miR-23b-5p inhibitor (P < 0.01). Conclusion miR-23b-5p ...
清肾颗粒含药血清通过miR-23b-5p靶向Nrf2通路减轻NRK-52E细胞转分化 刘敏, 金华, 呼琴, 陈诺, 张叶青, 王亿平 QingshenGranules-medicated serum reduces transdifferentiation of NRK-52E cells by miR-23b-5p-mediated activation of the Nrf2 pathway
摘要：目的探讨转化生长因子β1（TGF-β1）诱导NRK-52E （大鼠肾小管上皮细胞）细胞转分化模型中miR-23b-5p 是否能对Nrf2通路靶向调节，并阐明清肾颗粒含药血清减轻NRK-52E 细胞转分化的机制。方法构建TGF-β1诱导的NRK-52E 细胞转分化模型，分别使用miR-23b-5p mimic 、inhibitor 以及阴性对照（NC ）siRNA ...
23b-5p 是否能对 Nrf2 通路靶向调节,并阐明清肾颗粒含药血清减轻 NRK-52E 细胞转分化的机制.方法 构建 TGF-β1 诱导的 NRK-52E 细胞转分化 模型,分别使用 miR-23b-5p mimic,inhibitor 以及阴性对照(NC)siRNA 转染细胞;采用清肾颗粒含药血清进行干预,分为正常 组,TGF-β1 组,清肾颗粒组,miR-23b-mimic-...
miR-155,miR-23b,miR-21-5p和PD-1的表达水平.上调miR-155,miR-23b能够通过靶向于il12B和TAB2的3'UTR区来抑制TAB2,磷酸化的IκB和IL-12 p40的水平;上调miR-21-5p能够通过靶向于il12A的3'UTR区直接抑制LPS/R848诱导的IL-12p35表达.抑制miR-... 王晓亚,黄勇,童德文 - 中国兽医病理学学术研讨会暨兽医病理...
货号:cgr-miR-23b-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:cgr-miR-23b-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
货号:chi-miR-23b-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:chi-miR-23b-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
Growing evidence demonstrates that MicroRNAs (miRNAs) play an essential role in contributing to tumor development and progression. However, the underlying role and mechanisms of miR-23b-5p in hepatocellular carcinoma (HCC) formation remain unclear. Our s
Meng, F., Zhang, X., Wang, Y.et al.Correction: Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway.Cell Death Dis16, 137 (2025). https://doi.org/10.1038/s41419-025-07437-y ...
故除PI3K/AKT/PTEN通路外,miR-20b-5p可能通过其他通路促进损伤神经元神经突起及突触再生。其次,MG-LPS-EXOHT内共有19个microRNA较MG-LPS-EXONT显著升高,18个microRNA较MG-LPS-EXONT显著降低,除miR-20b-5p外,亚低温可能通过调控...