miR-221-5pblood-brain barrier dysfunctionAng-1Ang-2Tie-2subarachnoid hemorrhageAim To explore the potential role of microRNA miR-221-5p on the angiopoietin-1 (Ang-1)/Ang-2/Tie-2 signaling axis after subarachnoid hemorrhage (SAH) in a rat model.Methods Aspects of the rat's behavior were ...
货号:cgr-miR-221-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:cgr-miR-221-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
均可抑制鼻咽癌细胞SUNE1增殖,诱导凋亡,增强对顺铂的敏感性;miR-221-5p靶向负调控ALDH1A2的表达;低表达ALDH1A2可部分逆转miR-221-5p低表达对SUNE1细胞增殖,凋亡以及顺铂敏感性的影响.结论下调miR-221-5p可靶向促进ALDH1A2表达增强鼻咽癌SUNE1细胞的顺铂敏感性,抑制癌细胞增殖并诱导凋亡;miR-221-5p有望成为鼻咽癌...
There are comments on PubPeer for publication: miR-221-5p acts as an oncogene and predicts worse survival in patients of renal cell cancer (2019)
Up-regulation and silencing of miR-221-5p expression in prostate cancer cells are correlated with cell proliferation, migration and tumorigenesis, which suggest that miR-221-5p plays an important role in prostate cancer progression. 展开 关键词: Prostate cancer, miR-221-5p, SOCS1, Cell ...
human umbilical cord-derived MSCs; homing; cell engraftment; miR-9-5p; miR-221-3p; liver injury1. Introduction As multipotent adult stem cells that can be easily isolated and proliferated in vitro and possess strong plasticity and immunomodulatory function but no immunogenicity, mesenchymal stem ...
间充质干细胞外泌体具有间充质干细胞的生物学特性,并且其含有大量且种类繁多的蛋白质、细胞因子和生物活性物质。此外,间充质干细胞外泌体中的miRNA,可以调控基因表达,其比例比细胞更高,例如miR-155、let-7f、miR-199a、miR-221、miR-125b-5p和miR-22等,使得其能够参与多种生理和病理过程,起到对多项临床疾病...
(P<0.05).ROC曲线分析结果显示,血清miR-212-5p,miR-221-3p联合预测AECOPD预后不良的曲线下面积(AUC)为0.862,明显高于miR-212-5p,miR-221-3p单独预测的0.722,0.755(P<0.05).结论 AECOPD预后不良患者血清miR-212-5p,miR-221-3p水平下调可能与调节TLR4/NF-κB炎症信号通路有关,且miR-212-5p,miR-221-3p联合...
The combination of miRNA enrichment assay,analysis and molecular biological approaches revealed four novel CREB1-regulating miRNAs, namely miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p. Categorizing RCC samples as CREB1 negative or positive, respectively, the expression of these miRNAs was ...
miR-205-5p通过抑制UHRF1表达促进大鼠周围神经再生的研究进展