2022年6月21日,山东第一医科大学附属山东省眼科研究所阮庆国研究员/史伟云教授研究团队在Nature Communications在线发表了题为“MicroRNA-21 Promotes Pancreatic β cell Function through Modulating Glucose Uptake”的研究文章。该研究利用自...
近期,山东第一医科大学附属眼科研究所阮庆国研究员/史伟云教授研究团队在Nature Communications期刊(IF=17.694)发表了题为“MicroRNA-21 Promotes Pancreatic β cell Function through Modulating Glucose Uptake”的研究文章。研究发现胰岛β细胞中的miR-21促进胰岛素分泌,并揭示了miR-21在2型糖尿病中调节胰腺β细胞功能的...
一项发表于Nature Communications 2022的研究论文(MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake),通过制备胰岛β细胞特异miR-21缺失(miR-21βKO)小鼠,揭示了胰岛β细胞中的miR-21增强葡萄糖摄取,从而促进了GSIS的作用和机制。 本文采用高糖+高脂处理小鼠胰岛组织,分组为低糖(5.5...
8994—9000 25LawriC.H.MicroRNAsand l function. e, haemat0109y:smalmolecules,big Br. Haemat01. 137:503—512 J. 2007: 26 0huchida a1. MicroRNA一2l MoriyamaT, K, MizumotoK, et modulates of functions cancercel1s their bi0109ical pancreatic including andchemoresistance.M01CancerTher ...
研究表明，miR-21在2型糖尿病（T2D）患者和小鼠胰岛中高表达，但在其在胰腺β细胞功能调控中的作用仍然不明确。近期，阮庆国研究员/史伟云教授团队在Nature Communications期刊上发表了一篇题为“MicroRNA-21 Promotes Pancreatic β cell Function through Modulating Glucose Uptake”的文章，揭示了miR-21在...
been shown before to regulate the development and function of Tregs, it is until recently that researchers are beginning to realize the importance of miRNA on the regulation of Treg cell biology.We reviewed the current research progress of the regulation of Treg development and function by mir-21...
In cardiovascular disease, miR-92a has been shown to regulate endothelial cell function and angiogenesis, as well as cellular apoptosis and survival. In fibrosis, miR-92a has been shown to regulate tissue remodeling by targeting several ECM proteins, including collagen I and fibronectin. Let-7: ...
Simvastatin protects heart function and myocardial energy metabolism in pulmonary arterial hypertension induced right heart failure[J]. J Bioenerg Biomembr,2021,53(1):1-12.[21] Shin HJ,Kim H,Oh S,et al. AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy[J]. Nature,...
近日,来自山东第一医科大学、青岛大学、中国科学院深圳先进技术研究所的科研团队联合在《Nature Communications》杂志发表题为“MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake”的文章,发现miR-21可通过调节葡萄糖摄取促进胰腺β细胞功能。 研究人员通过敲除小鼠胰腺β细胞的miR-21,...
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