MicroRNAs are a class of 18–22-nucleotide noncoding RNAs that posttranscriptionally regulate gene expression and have been shown to play an important role during myoblast differentiation. In this study, we found that the expression of miR-145a-5p was gradually increased during C2C12 myoblast differ...
具体而言,新风胶囊通过上调miR-145-5p的表达,抑制Smads蛋白的磷酸化和核转位,从而抑制TGF-β超家族信号的传导。这一过程能够减轻RA患者的炎症反应,改善关节症状。此外,新风胶囊还可能通过其他途径(如调节免疫细胞功能、抑制细胞凋亡等)共同发挥抗炎、抗风湿作用。 五、结论 本文通过探讨新风胶囊通过miR-145-5p/Smads...
HR-HPV宫颈上皮内瘤变术后miR-145、miR-135a-5p、miR-365的表达与HR-H
To transfect miR-145a-5p into M2 microglia by Lipofectamine2000, and inject miR-145a-5p modified M2 microglia into the lesion sites of spinal cord for cell transplanted therapy. To evaluate the recovery of motor function in SCI mice through behavior analysis, immunofluorescence or histochemistry ...
molecules Article A Peptide Nucleic Acid against MicroRNA miR-145-5p Enhances the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Calu-3 Cells Enrica Fabbri 1, Anna Tamanini 2, Tiziana Jakova 3, Jessica Gasparello 1, Alex Manicardi 3,† ,ID Roberto Corradini ...
Our results suggested that miR-145-5p extended the G0-G1 phase, shortened S phase, inhibited cell proliferation and suppressed inflammatory responses in RMCs. Moreover, miR-145-5p inhibited CXCL16 protein expression through binding the 3'-UTR of CXCL16, suppressed AKT/GSK signaling pathway, and...
The miR-145-5p mimic was cotransfected into the cells alongside the pmirGLO-circRNA_0133711 plasmid (GeneSeed, China), and a corresponding control group was also established. In this study, the pRL-TK plasmid (Promega, USA) served as the control luciferase and was co-transfected into HEK293...