结果miR-1307-3p在乳腺癌细胞及乳腺癌组织中均显著上调.miR-1307-3p过表达可促进MCF-7细胞增殖和迁移;而miR-1307-3p inhibitor则抑制细胞迁移,并诱导凋亡.ISM1可能是miR-1307-3p的靶基因.乳腺癌组织中ISM1表达水平明显低于正常乳腺组织,且与临床病理分期有关.结论 miR-1307-3p可促进乳腺癌细胞增殖和迁移,可能...
There are comments on PubPeer for publication: miR-1307-3p promotes tumor growth and metastasis of hepatocellular carcinoma by repressing DAB2 interacting protein (2019)
Taken together, our findings suggest that miR-1307-3p is a oncogenic miRNA that significantly contributes to breast cancer development and progression, and inhibition of miR-1307-3p may be a novel strategy for inhibits breast cancer initiation and progression. 展开 关键词: breast cancer, ...
the overexpression of miR-1307-3p suppressed the deposition of cartilage matrix proteoglycans and decreased the expression of cartilage-related markers, including sex determining region Y-box 9, collagen type II 伪1 chain and aggrecan, whereas the knockdown of miR-1307-3p had the o...
Overexpression of miR-1307-3p suppressed the proliferation, promoted apoptosis and arrested cell cycle at G1 phase, meanwhile, downregulation of ISM1 accelerated the proliferation, inhibited apoptosis and promote cell cycleprogression. The result of dual luciferase reporter assay indicated that miR-1307-...
miR-1307-3pISM1ProliferationApoptosisBackground: colon adenocarcinoma (COAD) is the most common malignant tumor of gastrointestinal tract. Our study attempts to explore the effect of miR-1307-3p on biological function of COAD cells and its connection with isthmin 1 (ISM1)....
Functionally, miR-1307-3p knockdown inhibited the proliferation, migration and invasion of MHCC97H and HCCLM3 cells, and suppressed the in vivo growth and metastasis of HCCLM3 cells. Conversely, overexpression of miR-1307-3p facilitated Hep3B cell proliferation, migration and invasion. ...
MiR-1307-3pSOCS2ExosomesCancer therapyOur previous study has identified a novel circRNA (circDIDO1) that is down-regulated in gastric cancer (GC) and significantly inhibits GC progression. The purpose of this study is to identify the molecular mechanism for circDIDO1 and to evaluate the ...
miR-1307-3ps2m.The s2m, a highly conserved 41-nt hairpin structure in the SARS-CoV-2 genome, serves as an attractive therapeutic target that may have important roles in the virus life cycle or interactions with the host. However, the conserved s2m in Delta SARS-CoV-2, a previously ...