他们的工作发现:(1)过表达miR-130a-3p可以提高小鼠胰岛素敏感性;(2)miR-130a-3p主要通过作用于靶基因GRB10调节胰岛素敏感性;(3)db/db小鼠中过表达miR-130a-3p可以显著缓解胰岛素抵抗和脂肪肝,并且miR-130a-3p主要通过调节fas表达调节肝脏脂质代谢。 该研究为揭示miR-130a-3p在调节肝脏胰岛素敏感性和脂肪肝方面的...
miR‐130a‐3p, which directly targets SMAD4, is down‐regulated in ESCC. miR‐130a‐3p inhibits the migration and invasion of EC‐1 cells both in vitro and in vivo. Finally, miR‐130a‐3p inhibits TGF‐β‐induced EC‐1 cell migration, invasion, and EMT progression in a SMAD4‐dependent...
他们的工作发现:(1)过表达miR-130a-3p可以提高小鼠胰岛素(insulin)敏感性;(2)miR-130a-3p主要通过作用于靶基因GRB10调节胰岛素(insulin)敏感性;(3)db/db小鼠中过表达miR-130a-3p可以显著缓解胰岛素(insulin)抵抗和脂肪肝,并且miR-130a-3p主要通过调节fas表达调节肝脏脂质代谢。 该研究为揭示miR-130a-3p在调节肝脏...
miR-130a-3p的过表达通过诱导caspase依赖性凋亡基因的表达来促进HSC凋亡。si-TGFBR1和si-TGFBR2转染实验结果显示其对HSC功能的影响与miR-130a-3p一致。TGFBR1和TGFBR2减缓了由miR-130a-3p介导的Smad2、Smad3、Col-1和Col-4的mRNA及蛋白质表达水平的降低。 本研究结果表明miR-130a-3p在非酒精性纤维化脂肪性肝炎进...
gga-miR-130a-3p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:gga-miR-130a-3p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:gga-miR-130a-3p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对...
结果显示,与对照组相比,在注射胰岛素0.5,1.0 h以及连续注射14 d时,miR-146a-5p,miR-143a-3p,miR-125b-2表达显著下调(P<0.05),而miR-130a-3p表达显著上调(P<0.05),在2h 时检测的microRNA均不显著,且在1.0 h时下调与上调的趋势更显著;同时在1.0 h时检测糖类代谢以及脂类代谢相关基因的表达,发现GSK,HK,...
MiR-130a-3p inhibits the viability, proliferation, invasion, and cell cycle, and promotes apoptosis of nasopharyngeal carcinoma cells by suppressing BACH2 expression. Biosci Rep. 2017Jun 8;37(3):BSR20160576. (Open in a new window)Web of Science ®(Open in a new window)Google Scholar Qu...
MiR-130a-3p regulates FUNDC1-mediated mitophagy by targeting GJA1 in myocardial ischemia/reperfusion injury Yan Yan, Liu-yang Tian, Qian Jia, Yang Han, Yu Tian, Hui-ning Chen, Sai-jia Cui, Jie Xi, Yong-ming Yao & Xiao-jing Zhao Cell Death Discovery volume 9, Article num...
and silence of MAPK8 promoted proliferation inhibited apoptosis, suppressed inflammatory responses, and decreased the levels of VCAM-1, ICAM-1, and E-selectin, over-expression of MAPK8 partially restored the functional effects of miR-130a-3p on proliferation, inflammatory responses, and the expression...
学术范收录的Journal MiR-130a-3p regulates cell migration and invasion via inhibition of Smad4 in gemcitabine resistant hepatoma cells.,目前已有全文资源,进入学术范阅读全文,查看参考文献与引证文献,参与文献内容讨论。学术范是一个在线学术交流社区,收录论文