MCE 国际站:hsa-miR-542-5p antagomir 产品活性:hsa-miR-542-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链,全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制miRNA...
说明:cgr-miR-542-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录产物的翻译,从而起到转录后调控靶基因的表达。 miRNAs广泛存在于动物、植物、真...
542-5p visually attenuated a series of fibrotic lesions, including alveolar structural damage, alveolar interstitial thickening and silica-induced nodule formation. The down-regulation of miR-542-5p was also observed in mouse fibroblast (NIH-3T3) treated with transforming growth factor β1 (TGF-β1...
Moreover, the expression of miR-542-5p was upregulated in human osteosarcoma tissue compared with non-tumor adjacent tissue. Kaplan-Meier analysis revealed that overexpression of miR-542-5p predicted poor prognosis for osteosarcoma patients. Taken together, our results indicated that miR-542-5p ...
miR-542-5p is found to induce mitochondrial dysfunction and activation of SMAD2/3 phosphorylation [46], a signaling molecule downstream of transforming growth factor-β (TGF-β). TGF-β is a critical player in epithelial–mesenchymal transition, favoring tumor cell survival and dissemination [47]....
3.4功能性外泌体中miR-1249-5p基因表达 如图3所示,与对照组比较,模型组外泌体miR-1249-5pmRNA表达水平显著下降(P<0.01);与模型组比较,各给药组外泌体miR-1249-5pmRNA表达水平明显增加(P<0.05、0.001),而含药血清低剂量组miR-1249-5pm...
MCE 国际站:mmu-miR-542-5p agomir 产品活性:mmu-miR-542-5p agomir 是一种经过特殊化学修饰的miRNA模拟物,miRNA成熟链全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA agomir 可以模拟内源性miRNA,上调miRNA活性。与普通模拟物相比,miRNA agomir在动物...
miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin α6 in Silica-Induced Pulmonary Fibrosis.doi:10.3390/ijms19123717Silicosis... J Yuan,P Li,H Pan,... 被引量: 0发表: 2019年 Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and ...
miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin α6 in Silica-Induced Pulmonary Fibrosis miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin α6 in Silica-Induced Pulmonary FibrosisSilicosis, miRNA, integrin, fibroblast, proliferation... J Yuan,P Li,H Pan,... - 《...