Therefore, exosomal miR-21a-5p may serve as a novel therapeutic target for attenuating HALIviamodulation of the PGAM5-mediated necroptotic pathway.doi:10.1016/j.cellsig.2025.111677Ping YuanMedical College of Soochow University, 215123 Suzhou, Jiangsu, ChinaYunliang Cao...
MiR-21-5p is a well-studied “oncomiR” in multiple types of cancers with PTEN, PDCD4 and RECK as its best-known target genes. PTEN and PDCD4 have been previously shown to impede cancer cell growth and facilitate apoptosis, while RECK could reduce cancer cell mobility by deactivating matrix...
Following target prediction and dual-luciferase assay suggested that miR-21-5p played a role by combining with programmed cell death 4 (PDCD4), which was regulated by the long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) as a competing endogenous RNA (ceRNA). This study ...
Of the differentially expressed miRNAs, mmu-miR-21a is up-regulated. RT-qPCR also confirmed the up-regulation of mmu-miR-21a following decidualization in vivo and in vitro, and bioinformatic analysis and luciferase activity assay revealed Pdcd4 to be the target gene of mmu-miR-21a. Inhibition ...
Diminished levels of miR-100-5p were observed in arthritic sEVs, and its reintroduction alleviated proliferation and inflammation by targeting the mammalian target of rapamycin (mTOR) signaling. Overall, our study reveals the role of macrophages in exacerbating RA through the transfer of miR-100-5p...
15.在各种实施方式中,mir-10a-5p模拟物进一步包含药学上可接受的载体或佐剂。 16.另一方面,本发明提供了用于减轻受试者体重的方法,所述方法包括施用有效量 10b-5p。 38.在各种实施方式中,mir-10b-5p模拟物是哺乳动物的。 39.在各种实施方式中,mir-10b-5p模拟物是人的。
Integrating bioinformatics and experimental assays, we identified SATB2 as a direct downstream target of miR-211 in HCC cells. Complementary sequence of miR-211 was identified in the 3'UTR of SATB2 mRNA. Overexpression of miR-211 reduced SATB2 both mRNA and protein levels ...
In conclusion, miR-6315 may be a potential target in the treatment of SCI. Keywords: miR-6315, neural repair, primary spinal neurons, Smo, spinal cord injury Subjects: Bioinformatics, Cell Death & Injury, Gene Expression & Regulation, Molecular Interactions, Neuroscience ...
方法:(1)生物信息学分析:GEO数据库中查找到了糖尿病心衰病人心肌组织样本中micro RNA表达谱数据,下载相关数据并分析mi R-155在糖尿病心衰病人心肌中的表达差异;通过Target Scan7.2,mi RDB在线数据库预测人源和鼠源mi R-155的下游靶点,选取两个数据库的交集靶基因,行GO富集分析(2)体外实验:(1)选取MCFs作为体外...
ON-TARGETplus Non-targeting Pool Dharmacon Cat# D-001810-10-05 miRIDIAN microRNA mmu-miR-21a-5p mimic Dharmacon Cat# C-310515-05-0005 miRIDIAN microRNA Mimic Negative Control #1 Dharmacon Cat# CN-001000-01-05 Recombinant DNA CSCW2.palmGFP Lai et al., 2015, McCabe and Berthiaume, 1999 ...