在体内和体外模型中,研究者进一步发现G-exo内富含的miRNA-21-5p可保护RGC损伤,并抑制小胶质细胞的过度激活。 图1. TG-exo可减轻视网膜缺血再灌注所致RGC凋亡损伤 图2. TG-exo内的miR-21-5p介导了对视网膜损伤保护作用 图3. TG-...
研究发现,miR-21-5p 在 LUAD 组织和细胞中的表达明显高于相邻组织和人支气管上皮细胞,而 WWC2则明显低于相邻组织和细胞。双荧光素酶报告基因检测显示,miR-21-5p靶向WWC2并下调其表达。此外,沉默miR-21-5p或过表达WWC2对PC-9癌细胞的增殖、迁移和侵袭均有抑制作用,当miR-21-5p过表达时,这种作用被抑制。 然...
图3. TG-exo内的miR-21-5p介导了炎症抑制和对RGC的保护作用 综上所述,该研究报道了间充质干细胞来源的外泌体富含miR-21a-5p能够保护造成的视网膜神经细胞损伤,并且首次发现TNF-α预处理干细胞可增强其外泌体的神经保护作用。为视网膜神经损伤治疗提供了新的治疗方向,并为MSC来源的外泌体在神经致盲性眼病的临床...
Objective: To investigate the mechanism by which the identity transcription factor (BNC2) of myoblasts targeted by miR-21-5p in controling the proliferation, migration, and invasion of esophageal cancer (ESCA) cells. Methods: Real-time quantitative polymerase chain reaction...
hsa-miR-21-5p mimic | hsa-miR-21-5p 模拟物 | MedChemExpress (MCE) 产品官方链接 价格:2200 品牌:MedChemExpress (MCE) 产地:美国 最新更新日期:2024-09-14 16:42 我要询单 QQ交流 MedChemExpress LLC VIP会员 公司: MedChemExpress LLC 联系人:高欢 联系电话: 13611715263 021-58955995 联系邮箱...
We found that PMCs could internalize GC-derived exosomal miR-21-5p and led to increased levels of miR-21-5p in PMCs. Through various types of in vitro and in vivo assays, we confirmed that exosomal miR-21-5p was able to induce MMT of PMCs and promote tumor peritoneal metastasis. More...
Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells.
10, 11, 12,14, 15 miR-21 (hsa-miR-21-5p) is an oncomiR located on chromosome 17 that is expressed widely in tumors,16, 17 where it promotes cell proliferation. miR-21 is considered an osteoblastic miRNA, with roles in bone differentiation and development, and osteoblast differentiation ...
结果EMT患者在位和异位子宫内膜组织miR-515-5p相对表达量显著高于正常子宫内膜组织(均P<0.001),ITLN2 mRNA相对表达量显著低于正常子宫内膜组织,异位子宫内膜组织ITLN2 mRNA相对表达量显著低于在位子宫内膜组织(均P<0.001),EMT患者异位子...