miR-199a-5p目的研究miR.199a-Sp在血管紧张素Ⅱ(AngII)导致肥大心肌细胞中的表达变化。方法雄性sD大鼠30只,采用完全随机方法将其分为假手术组、模型组、氯沙坦组[10mg/(kg·d)],每组10只。制备腹主动脉缩窄致心肌肥大模型,在术后第28天,检测心脏质量指数和左心室质量指数,HE染色观察左心室心肌细胞肥大情况,...
Guo W, Qiu Z, Wang Z, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, et al: MiR‑199a‑5p is negatively associated with malignancies and regulates glycolysis and lactate produc‑ tion by targeting hexokinase 2 in liver cancer. ...
Importanly, miR-199a-5p-induced abnormal cellular lipid accumulation could be markedly reversed by overexpression of MST1. Conclusion: miR-199a-5p might be an essentail regulator for hepatic lipid metabolism, possibly through its interction with MST1 and the subsequent signaling cascade. Thus, ...
研究结果表明 血浆miR-199a-5p在中性粒细胞型哮喘患者中表达明显升高并可能通过调节炎症反应及肺功能参与哮喘发生、发展。血浆miR-199a-5p有望成为中性粒细胞型哮喘的生物标志物,其临床价值及在哮喘发病机制中的具体作用值得进一步探讨。 作者介绍
结果病毒感染KFs 48 h后,hsa-miR-199a-5p组的hsa-miR-199a-5p表达量明显高于rLv-NC组和空白对照组,差异有统计学意义(P<0.01);与rLv-NC组和空白对照组相比,hsa-miR-199a-5p组的细胞增殖率、侵袭性均有所降低,细胞凋亡率...
Moreover, exosome miR-199a-5p and MMP2 derived from serum possess potential as future biomarkers for vascular injury.BioMed CentralArthritis Research & TherapyShuning Guohttps://ror.org/02drdmm93grid.506261.60000 0001 0706 7839Department of Rheumatology and Clinical Immunology, Peking Union Medical ...
MicroRNAs (miRNAs) are known to contribute to many metabolic diseases, including diabetes. In this study, we investigated the role of miR199a-5p in the regulation of hepatic insulin sensitivity. Ad-anti-miR199a-5p adenoviruses were injected into male C57
近日,来自重庆医科大学附属第一医院泌尿外科的研究人员发现,BMSCs通过分泌包含有靶向BIP的miR-199a-5p的外泌体来保护肾脏缺血再灌注损伤,并在再灌注的早期阶段抑制内质网应激。该研究发表于杂志The FASEB Journal上。 肾缺血/再灌注(I/R)损伤是急性肾损伤(AKI)和肾衰竭的主要原因,在全世界范围内造成高死亡率。
通过过表达(转染miRNA mimic)和抑制(转染miRNA inhibitor)miR-199a-5p,使用q RT-PCR方法和Western blot技术检测靶基因ABCA1表达量,并通过TG测定和油红O染色检测miR-199a-5p干预VPA致肝细胞脂质累积的影响.结果:1.通过q RT-PCR方法对采用VPA治疗的癫痫患儿血清中测定9种miRNAs.比较两组癫痫患儿血清中miRNAs表达...