预测CircHMGB2可能通过海绵吸附miR-181a-5p来发挥其生物学功能,CARM1为CircHMGB2的下游mRNA,荧光素酶报告实验表明,与突变体CARM1序列相比,CARM1野生型荧光素酶活性减少 (Fig. 3H,I)。qRT-PCR也显示在H1299-shCircHMGB2细胞中,...
预测CircHMGB2可能通过海绵吸附miR-181a-5p来发挥其生物学功能,CARM1为CircHMGB2的下游mRNA,荧光素酶报告实验表明,与突变体CARM1序列相比,CARM1野生型荧光素酶活性减少(Fig. 3H,I)。qRT-PCR也显示在H1299-shCircHMGB2细胞中,CARM1的表达降低(Fig. 3J),而在H1299-shCircHMGB2细胞中,敲除miR-181a-5p的表达...
Further experiments demonstrated that knockdown of MALAT1 inhibited the GC cells proliferation and invasion. Mechanistically, we found that MALAT1 functioned as a molecular sponge for miR-1297, antagonizing its ability to inhibit HMGB2 protein expression. To sum up, our findings revealed that MALAT1...
HMGB2蛋白表达,克隆形成数减少,miR-188-3p表达,细胞抑制率与凋亡率增加(P<0.05).与con组和miR-NC组相比,miR-188-3p组miR-188-3p表达,细胞抑制率与凋亡率增加,HMGB2蛋白表达,克隆形成数减少(P<0.05).circ_0008035靶向miR-188-3p,miR-188-3p靶向HMGB2.si-circ_0008035+anti-miR-188-3p组miR-188-3p表达,...
Previous researches have shown the role of miR-23b-5p in a variety of pathological and physiological processes. Oumarou et al.7 found that miR-23b-5p was involved in promotion of cardiac hypertrophy and dysfunction via activating HMGB2 signaling pathway. You et al.8 confirmed the role of ...
Reporter gene assay and western blot analysis showed that ATG12 and HMGB2 were the direct targets of miR-23b-3p. Meanwhile, ATG12 and HMGB2 were positively associated with the occurrence of autophagy. Reducing the expression of these target genes by siRNA or inhibition of autophagy both ...
in a xenograft model of human MM, RP11-301G19.1 knockdown significantly inhibited tumour growth by downregulating HMGB2. Overall, our data demonstrated that RP11-301G19.1 is involved in MM cell proliferation by sponging miR-582-5p and may serve as a therapeutic target for MM....
Mir-142-3p simultaneously targets HMGA1, HMGA2, HMGB1, and HMGB3 and inhibits tumorigenic properties and in-vivo metastatic potential of human Cervical cancer cells. Life Sci. 2022;291:120268. Article CAS PubMed Google Scholar Aoki M, Jiang H, Vogt PK. Proteasomal degradation of the FoxO1...
Functionally, we revealed that MALAT1 promoted cells proliferation and invasion in GC. Mechanistically, our results demonstrated that MALAT1 was negatively correlation with miR-1297 and functioned as a molecular sponging miR-1297, antagonizing its ability to suppress HMGB2 expression. Taken together, ...
LINC00184 affected the cell cycle, proliferation, apoptosis, migration and invasion in NSCLC via regulation of the miR-524-5p/HMGB2 axis.doi:10.1111/jcmm.16247W.WangL.LiL.ZhaoJ Cell Mol MedJournal of cellular and molecular medicine