This study investigated the relationship between eye movement parameters and cognitive function in patients with mild to moderate Alzheimer’s disease (AD). A total of 80 patients with AD (mild and moderate) and 34 normal controls (NC) participated. Neuropsychological assessments were conducted using...
The aim of this study was to assess efficacy and safety of neuroEPO plus. Methods This was a double-blind, randomized, placebo-controlled, phase 2–3 trial involving participants ≥ 50 years of age with mild-to-moderate AD clinical syndrome. Participants were randomized in a 1:1:1 ...
It remains unclear what contributes most to these clinical differences in the RDP subgroup. It is possible that this group harbors some cases of well-known PD mimics, which can be very difficult to distinguish clinically such as Multiple System Atrophy.47 Future research exploring the longitudinal ...
Four control subjects had small to moderate numbers of AGs in ventromedial temporal lobe structures. Three patients with MCI had small to moderate numbers of AGs in ventromedial temporal lobe structures, including the ambient gyrus. All of the patients met only stage 1 or stage 2 classifications ...
Additionally, we examined whether the GM density of individual brain regions or the atrophy synchronization of brain regions was more sensitive to the early stages of MCI development and reversion. Based on the automated anatomical atlas (http://www.gin.cnrs.fr/AAL), we identified the clusters ...
Mild cognitive impairment (MCI) is a transitional phase between normal cognitive aging and dementia. As the world population is aging rapidly, more MCI patients will be identified, posing significant problems to society. Normal aging is associated with c
T. Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer's disease. Arch Neurol 62, 425–430 (2005). 67. Raichle, M. E. et al. A default mode of brain function. Proc Natl Acad Sci USA 98, 676–682 (2001). 68. Rombouts, S. A., ...
Tai Chi focuses on tranquility of mind to achieve longevity through meditation and life style modification [26]. It is an alternate form of aerobic exercise with moderate intensity [27]. Aerobic exercise can delay age-related brain atrophy, increase cerebral blood circulation, and stimulate neural ...
Further, this profile corresponds partially to the decline (not yet in severity) most frequently reported in mild to moderate AD28,29. These results add to the inconsistent literature on the relationship between subjective complaints and objective cognitive performance5. Striepens et al.14 reported ...
The pathophysiology of cognitive decline in the diabetic brain has aroused much interest owing to its high incidence. Neuroimaging techniques can provide important clues regarding brain structure and function for understanding the neurological involvement in T2DM patients. Morphological atrophy was considered ...